Prognostic value of unrelated atypical serum immunofixation patterns during Multiple Myeloma therapy

• Main Authors: Guimarães Cristina, Bergantim Rui, Ramalho Renata, Couto Nuno, Guimarães João T, Trigo Fernanda
• Format: Article
• Language: English
• Published: BMC 2012-06-01
• Series: Journal of Hematology & Oncology
• Subjects: Multiple myeloma; Autologous stem cell transplantation; Marker of prognosis; Serum immunofixation patterns
• Online Access: http://www.jhoonline.org/content/5/1/33
• ISSN: 1756-8722

<p>Abstract</p> <p>Autologous stem cell transplantation (ASCT) is the gold standard therapy for suitable multiple myeloma (MM) patients after induction with high dose therapy. To date, the evidence of a reliable marker of prognosis in these cases remains scarce. Our aim was to evaluate appearance of unrelated atypical serum immunofixation patterns (ASIPs) as a marker of prognosis in MM patients submitted to ASCT. We retrospectively analysed data from 65 patients. Interestingly, we observed that presence of ASIPs was associated with longer progression-free survival and longer overall survival. Our results suggested that presence of ASIPs could be a novel marker of good prognosis in MM patients submitted to ASCT.</p>