Moderate Modulation of Cardiac PGC-1α Expression Partially Affects Age-Associated Transcriptional Remodeling of the Heart

Moderate Modulation of Cardiac PGC-1α Expression Partially Affects Age-Associated Transcriptional Remodeling of the Heart

Aging is associated with a decline in cardiac function due to a decreased myocardial reserve. This adverse cardiac remodeling comprises of a variety of changes, including a reduction in mitochondrial function and a decline in the expression of the peroxisome proliferator-activated receptor γ coactiv...

Full description

Bibliographic Details
Main Authors: Natasha Whitehead, Jonathan F. Gill, Marijke Brink, Christoph Handschin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Physiology
Subjects:
PGC-1α
aging
myocardium
remodeling
transcriptional regulation
heart
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00242/full

Similar Items

Similar Items