Interleukin-10 serum level in acute coronary syndrome patients
<p><strong>Aim</strong> To compare plasma IL-10 concentrations in patients with Acute Coronary Syndrome (ACS) with those in Coronary Artery Disease (CAD).</p><p><strong>Methods</strong> ACS patients hospitalized in intensive coronary care unit (ICCU) of Cipt...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine Universitas Indonesia
2009-09-01
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| Series: | Medical Journal of Indonesia |
| Online Access: | http://mji.ui.ac.id/journal/index.php/mji/article/view/358 |
| Summary: | <p><strong>Aim</strong> To compare plasma IL-10 concentrations in patients with Acute Coronary Syndrome (ACS) with those in Coronary Artery Disease (CAD).</p><p><strong>Methods</strong> ACS patients hospitalized in intensive coronary care unit (ICCU) of Cipto Mangunkusumo Hospital/Faculty of Medicine University of Indonesia (CMH/FMUI), Persahabatan Hospital, MMC Hospital, and Medistra Hospital, Jakarta, between May 2005 and May 2006, were included in this study. The ambulatory CAD patients were taken as comparator. The serum IL-10 level was measured by immunoassay method, and compared by using Independent Student’s t-test. To investigate whether IL-10 serum level could predict ACS, the sensitivity and specificity of this parameter towards ACS in various IL-10 serum levels were calculated as well.</p><p><strong>Results</strong> In this observational study, as many as 146 subjects were analyzed, consisting of 84 ACS patients, and 62 coronary artery disease (CAD). The IL-10 level was higher in the group of ACS patients (7.37 pg/mL + 7.81, CI 95% 5.68-9.07) than that in CAD patients (1.59 pg/mL + 1.55, CI 95% 1.2-1.98). The optimal cut-off point for serum IL-10<br />level is >1.95 pg/mL, with 79.76 % sensitivity and 77.42 % specificity.</p><p><strong>Conclusion</strong> The IL-10 level was higher in the ACS patients compared to that in CAD patients. Serum IL-10 measurement is a quite superior method to distinguish acute and stable condition, eventhough it is not as good as hsCRP for the same purpose. <em><strong>(Med J Indones 2009;18:165-9)</strong></em></p><p><strong>Key words:</strong> <em>Interleukin-10, acute coronary syndrome</em></p> |
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| ISSN: | 0853-1773 2252-8083 |