Prognostic Impact of Tumor-Associated Macrophages on Survival Is Checkpoint Dependent in Classical Hodgkin Lymphoma

Prognostic Impact of Tumor-Associated Macrophages on Survival Is Checkpoint Dependent in Classical Hodgkin Lymphoma

Tumor microenvironment and immune escape affect pathogenesis and survival in classical Hodgkin lymphoma (cHL). While tumor-associated macrophage (TAM) content has been associated with poor outcomes, macrophage-derived determinants with clinical impact have remained undefined. Here, we have used mult...

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Bibliographic Details
Main Authors: Kristiina Karihtala, Suvi-Katri Leivonen, Oscar Brück, Marja-Liisa Karjalainen-Lindsberg, Satu Mustjoki, Teijo Pellinen, Sirpa Leppä
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
classical hodgkin lymphoma
tumor-associated macrophages
tumor microenvironment
checkpoint molecules
multiplex immunohistochemistry
survival
Online Access:https://www.mdpi.com/2072-6694/12/4/877

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