Peroxisome proliferator-activated receptor-gamma: potential molecular therapeutic target for HIV-1-associated brain inflammation

Peroxisome proliferator-activated receptor-gamma: potential molecular therapeutic target for HIV-1-associated brain inflammation

Abstract Background Despite the use of combination antiretroviral therapy for the treatment of HIV-1 infection, cognitive impairments remain prevalent due to persistent viral replication and associated brain inflammation. Primary cellular targets of HIV-1 in the brain are macrophages, microglia, and...

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Bibliographic Details
Main Authors: Amila Omeragic, Md Tozammel Hoque, U-yeong Choi, Reina Bendayan
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Journal of Neuroinflammation
Subjects:
HIV-1ADA gp120
PPARγ
HIV-1
Brain inflammation
Cytokines
Glutamate
Online Access:http://link.springer.com/article/10.1186/s12974-017-0957-8

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