Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine

Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine

Adolescents are especially prone to drug addiction, but the underlying biological basis of their increased vulnerability remains unknown. We reveal that translational control by phosphorylation of the translation initiation factor eIF2α (p-eIF2α) accounts for adolescent hypersensitivity to cocaine....

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Bibliographic Details
Main Authors: Wei Huang, Andon N Placzek, Gonzalo Viana Di Prisco, Sanjeev Khatiwada, Carmela Sidrauski, Krešimir Krnjević, Peter Walter, John A Dani, Mauro Costa-Mattioli
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
ventral tegemental area
long-term potentiation (LTP)
long-term depression (LTD)
protein synthesis
cocaine
Online Access:https://elifesciences.org/articles/12052

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