Gemcitabine Induces Microvesicle Particle Release in a Platelet-Activating Factor-Receptor-Dependent Manner via Modulation of the MAPK Pathway in Pancreatic Cancer Cells

Gemcitabine Induces Microvesicle Particle Release in a Platelet-Activating Factor-Receptor-Dependent Manner via Modulation of the MAPK Pathway in Pancreatic Cancer Cells

Studies, including ours, have shown that pro-oxidative stressors, such as chemotherapeutic agents, generate oxidized lipids with agonistic platelet-activating factor (PAF) activity. Importantly, recent reports have implicated that these PAF-agonists are transported extracellularly via microvesicle p...

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Bibliographic Details
Main Authors: Anita Thyagarajan, Sayali M. Kadam, Langni Liu, Lisa E. Kelly, Christine M. Rapp, Yanfang Chen, Ravi P. Sahu
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:International Journal of Molecular Sciences
Subjects:
pancreatic cancer
platelet-activating factor-receptor
gemcitabine
microvesicle particles
Online Access:http://www.mdpi.com/1422-0067/20/1/32

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