Alterations of sirtuins in mitochondrial cytochrome c-oxidase deficiency.

Alterations of sirtuins in mitochondrial cytochrome c-oxidase deficiency.

Sirtuins are NAD+ dependent deacetylases, which regulate mitochondrial energy metabolism as well as cellular response to stress. The NAD/NADH-system plays a crucial role in oxidative phosphorylation linking sirtuins and the mitochondrial respiratory chain. Furthermore, sirtuins are able to directly...

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Bibliographic Details
Main Authors: Arne Björn Potthast, Theresa Heuer, Simone Johanna Warneke, Anibh Martin Das
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5653369?pdf=render

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