Challenges in Management of Primary Hypoparathyroidism Associated with Autoimmune Polyglandular Syndrome Type 1

Challenges in Management of Primary Hypoparathyroidism Associated with Autoimmune Polyglandular Syndrome Type 1

We report a case of autoimmune polyglandular syndrome type 1 (APS1) complicated by severe vascular insufficiency due to diffuse vascular calcification. APS1 is characterised clinically by multiple autoimmune conditions and development of at least two components of the triad of mucocutaneous candidia...

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Main Authors: I. R. Wallace, V. McConnell, P. M. Bell, J. R. Lindsay
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Case Reports in Endocrinology
Online Access:http://dx.doi.org/10.1155/2011/281758
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spelling doaj-51fca806519342e0ae726d45b8d0b0742020-11-24T23:09:08ZengHindawi LimitedCase Reports in Endocrinology2090-65012090-651X2011-01-01201110.1155/2011/281758281758Challenges in Management of Primary Hypoparathyroidism Associated with Autoimmune Polyglandular Syndrome Type 1I. R. Wallace0V. McConnell1P. M. Bell2J. R. Lindsay3Department of Endocrinology and Diabetes, Altnagelvin Area Hospital, Londonderry BT47 6SB, UKNorthern Ireland Regional Genetics Service, Belfast City Hospital, Belfast BT9 7AB, UKRegional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, UKDepartment of Endocrinology and Diabetes, Altnagelvin Area Hospital, Londonderry BT47 6SB, UKWe report a case of autoimmune polyglandular syndrome type 1 (APS1) complicated by severe vascular insufficiency due to diffuse vascular calcification. APS1 is characterised clinically by multiple autoimmune conditions and development of at least two components of the triad of mucocutaneous candidiasis, hypoparathyroidism, and autoimmune adrenal insufficiency. We highlight the problems in current serum calcium monitoring methods and suggest that fluctuations in serum calcium concentrations due to difficulties treating hypoparathyroidism may have contributed to the vascular calcification seen in this case.http://dx.doi.org/10.1155/2011/281758
collection DOAJ
language English
format Article
sources DOAJ
author I. R. Wallace
V. McConnell
P. M. Bell
J. R. Lindsay
spellingShingle I. R. Wallace
V. McConnell
P. M. Bell
J. R. Lindsay
Challenges in Management of Primary Hypoparathyroidism Associated with Autoimmune Polyglandular Syndrome Type 1
Case Reports in Endocrinology
author_facet I. R. Wallace
V. McConnell
P. M. Bell
J. R. Lindsay
author_sort I. R. Wallace
title Challenges in Management of Primary Hypoparathyroidism Associated with Autoimmune Polyglandular Syndrome Type 1
title_short Challenges in Management of Primary Hypoparathyroidism Associated with Autoimmune Polyglandular Syndrome Type 1
title_full Challenges in Management of Primary Hypoparathyroidism Associated with Autoimmune Polyglandular Syndrome Type 1
title_fullStr Challenges in Management of Primary Hypoparathyroidism Associated with Autoimmune Polyglandular Syndrome Type 1
title_full_unstemmed Challenges in Management of Primary Hypoparathyroidism Associated with Autoimmune Polyglandular Syndrome Type 1
title_sort challenges in management of primary hypoparathyroidism associated with autoimmune polyglandular syndrome type 1
publisher Hindawi Limited
series Case Reports in Endocrinology
issn 2090-6501
2090-651X
publishDate 2011-01-01
description We report a case of autoimmune polyglandular syndrome type 1 (APS1) complicated by severe vascular insufficiency due to diffuse vascular calcification. APS1 is characterised clinically by multiple autoimmune conditions and development of at least two components of the triad of mucocutaneous candidiasis, hypoparathyroidism, and autoimmune adrenal insufficiency. We highlight the problems in current serum calcium monitoring methods and suggest that fluctuations in serum calcium concentrations due to difficulties treating hypoparathyroidism may have contributed to the vascular calcification seen in this case.
url http://dx.doi.org/10.1155/2011/281758
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AT vmcconnell challengesinmanagementofprimaryhypoparathyroidismassociatedwithautoimmunepolyglandularsyndrometype1
AT pmbell challengesinmanagementofprimaryhypoparathyroidismassociatedwithautoimmunepolyglandularsyndrometype1
AT jrlindsay challengesinmanagementofprimaryhypoparathyroidismassociatedwithautoimmunepolyglandularsyndrometype1
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