Apoptosis repressor with caspase recruitment domain (ARC) promotes bone regeneration of bone marrow-derived mesenchymal stem cells by activating Fgf-2/PI3K/Akt signaling

Apoptosis repressor with caspase recruitment domain (ARC) promotes bone regeneration of bone marrow-derived mesenchymal stem cells by activating Fgf-2/PI3K/Akt signaling

Abstract Objectives This study aims to investigate whether apoptosis repressor with caspase recruitment domain (ARC) could promote survival and enhance osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). Materials and methods The lentivirus transfection method was used...

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Bibliographic Details
Main Authors: Longwei Hu, Yang Wang, Hongya Pan, Kathreena Kadir, Jin Wen, Siyi Li, Chenping Zhang
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Stem Cell Research & Therapy
Subjects:
ARC
BMSCs
Osteogenic differentiation
Fgf-2
Online Access:https://doi.org/10.1186/s13287-021-02253-5

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