Chemotherapy-Induced Degradation of Glycosylated Components of the Brain Extracellular Matrix Promotes Glioblastoma Relapse Development in an Animal Model

Chemotherapy-Induced Degradation of Glycosylated Components of the Brain Extracellular Matrix Promotes Glioblastoma Relapse Development in an Animal Model

Adjuvant chemotherapy with temozolomide (TMZ) is an intrinsic part of glioblastoma multiforme (GBM) therapy targeted to eliminate residual GBM cells. Despite the intensive treatment, a GBM relapse develops in the majority of cases resulting in poor outcome of the disease. Here, we investigated off-t...

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Bibliographic Details
Main Authors: Alexandra Y. Tsidulko, Oleg B. Shevelev, Anna S. Khotskina, Mariia A. Kolpakova, Anastasia V. Suhovskih, Galina M. Kazanskaya, Alexander M. Volkov, Svetlana V. Aidagulova, Evgenii L. Zavyalov, Elvira V. Grigorieva
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
glioblastoma multiforme
chemotherapy
extracellular matrix
proteoglycan
glycosaminoglycan
chondroitin sulfate
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.713139/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.713139/full

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