Shear Stress Triggers Angiogenesis of Late Endothelial Progenitor Cells via the PTEN/Akt/GTPCH/BH4 Pathway

Shear Stress Triggers Angiogenesis of Late Endothelial Progenitor Cells via the PTEN/Akt/GTPCH/BH4 Pathway

Background. Shear stress is an effective modulator of endothelial progenitor cells (EPCs) and has been suggested to play an important role in angiogenesis. The phosphatase and tensin homolog (PTEN)/Akt and guanosine triphosphate cyclohydrolase (GTPCH)/tetrahydrobiopterin (BH4) pathways regulate the...

Full description

Bibliographic Details
Main Authors:	Shao-Hong Wu, Feng Zhang, Shun Yao, Lu Tang, Hai-Tao Zeng, Ling-Ping Zhu, Zhen Yang
Format:	Article
Language:	English
Published:	Hindawi Limited 2020-01-01
Series:	Stem Cells International
Online Access:	http://dx.doi.org/10.1155/2020/5939530

Similar Items

Nicotine Enhances the Therapeutic Angiogenesis of Human Late Endothelial Progenitor Cells
by: Liu, Chun-Chieh, et al.
Published: (2014)

Design and synthesis of GTPCH-I inhibitors and related compounds via solution and solid phase
by: La Rosa, Salvatore
Published: (2002)

Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling.
by: Hasan Korkaya, et al.
Published: (2009-06-01)

Glucocerebroside reduces endothelial progenitor cell-induced angiogenesis
by: Hsiang-Ping Lee, et al.
Published: (2019-01-01)

Downregulated GTCPH I/BH4 Pathway and Decreased Function of Circulating Endothelial Progenitor Cells and Their Relationship with Endothelial Dysfunction in Overweight Postmenopausal Women
by: Ying Luo, et al.
Published: (2018-01-01)

PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis
by: Naoko Okumura, et al.
Published: (2012-01-01)

The Role of PTEN in Tumor Angiogenesis
by: Stéphane Rodriguez, et al.
Published: (2012-01-01)

Endothelial Progenitor Cell-Derived Microvesicles Promote Angiogenesis in Rat Brain Microvascular Endothelial Cells In vitro
by: Wen Zeng, et al.
Published: (2021-02-01)

Plumbagin suppresses endothelial progenitor cell-related angiogenesis in vitro and in vivo
by: Hsiang-Ping Lee, et al.
Published: (2019-01-01)

Endothelial progenitor cells in systemic sclerosis: their possible role in angiogenesis
by: N. Fracchiolla, et al.
Published: (2011-09-01)

Endothelial Progenitor Cells in Tumor Angiogenesis: Another Brick in the Wall
by: Marina Marçola, et al.
Published: (2015-01-01)

Role of Endothelial progenitor cells in angiogenesis with the approach of physical activity
by: sharif rezaee, et al.
Published: (2020-05-01)

Mature and progenitor endothelial cells perform angiogenesis also under protease inhibition: the amoeboid angiogenesis
by: Anastasia Chillà, et al.
Published: (2018-04-01)

PTEN suppresses tumorigenesis by directly dephosphorylating Akt
by: Lang Bu, et al.
Published: (2021-07-01)

Soya-cerebroside inhibits VEGF-facilitated angiogenesis in endothelial progenitor cells
by: Hsiang-Ping Lee, et al.
Published: (2020-01-01)

Mutant human torsinA, responsible for early-onset dystonia, dominantly suppresses GTPCH expression, dopamine levels and locomotion in Drosophila melanogaster
by: Noriko Wakabayashi-Ito, et al.
Published: (2015-07-01)

Prolonged Fasting Improves Endothelial Progenitor Cell-Mediated Ischemic Angiogenesis in Mice
by: Bao Xin, et al.
Published: (2016-11-01)

Anti-angiogenesis triggers exosomes release from endothelial cells to promote tumor vasculogenesis
by: Ye Zeng, et al.
Published: (2019-12-01)

AKT/IKKα/VAV1 SIGNALING IN ENDOTHELIAL CELL SURVIVAL AND ANGIOGENESIS
by: DeBusk, Laura M
Published: (2008)

THRIL mediates endothelial progenitor cells autophagy via AKT pathway and FUS
by: Jiandong Xiao, et al.
Published: (2020-09-01)

CXCL13 promotes angiogenesis in endothelial progenitor cells: potential implications for rheumatoid arthritis
by: Chao-Ju Chen, et al.
Published: (2018)

Ultrasonic microbubble VEGF gene delivery improves angiogenesis of senescent endothelial progenitor cells
by: Yi-Nan Lee, et al.
Published: (2021-06-01)

Visfatin Increases VEGF-dependent Angiogenesis of Endothelial Progenitor Cells during Osteoarthritis Progression
by: Chun-Hao Tsai, et al.
Published: (2020-05-01)

Distinct role of autophagy on angiogenesis: highlights on the effect of autophagy in endothelial lineage and progenitor cells
by: Mehdi Hassanpour, et al.
Published: (2018-11-01)

Monocytes as Endothelial Progenitor Cells (EPCs), Another Brick in the Wall to Disentangle Tumor Angiogenesis
by: Filipa Lopes-Coelho, et al.
Published: (2020-01-01)

Rosuvastatin enhances angiogenesis via eNOS-dependent mobilization of endothelial progenitor cells.
by: Junlan Zhou, et al.
Published: (2013-01-01)

Aliskiren Improved the Endothelial Repair Capacity of Endothelial Progenitor Cells from Patients with Hypertension via the Tie2/PI3k/Akt/eNOS Signalling Pathway
by: Shun Yao, et al.
Published: (2020-01-01)

Research of PTEN mutation in glioma stem/progenitor cells
by: Yao⁃dong ZHAO, et al.
Published: (2010-12-01)

MicroRNA-22 Induces Endothelial Progenitor Cell Senescence by Targeting AKT3
by: Yue Zheng, et al.
Published: (2014-10-01)

The effects of leptin and astrocyte conditioned medium on ischemia-triggered endothelial cell permeability and angiogenesis
by: Chang-Hung Lin, et al.
Published: (2013)

Endothelial progenitor cell-conditioned medium promotes angiogenesis and is neuroprotective after spinal cord injury
by: Tao Wang, et al.
Published: (2018-01-01)

Control of microenvironmental cues with a smart biomaterial composite promotes endothelial progenitor cell angiogenesis
by: A Aguirre, et al.
Published: (2012-07-01)

Impact of obesity control on circulating level of endothelial progenitor cells and angiogenesis in response to ischemic stimulation
by: Chen Yung-Lung, et al.
Published: (2012-07-01)

Endothelial progenitor cells physiology and metabolic plasticity in brain angiogenesis and blood-brain barrier modeling
by: Natalia Malinovskaya, et al.
Published: (2016-12-01)

Butein Inhibits Angiogenesis of Human Endothelial Progenitor Cells via the Translation Dependent Signaling Pathway
by: Ching-Hu Chung, et al.
Published: (2013-01-01)

Effect and mechanism of thrombospondin-1 on the angiogenesis potential in human endothelial progenitor cells: an in vitro study.
by: Qing Qin, et al.
Published: (2014-01-01)

Studies on angiogenesis of natural product WJO00 and its derivatives in human endothelial progenitor cell
by: Cho-Yun Chia, et al.
Published: (2012)

Loss of Pten promotes angiogenesis and enhanced vegfaa expression in zebrafish
by: Suma Choorapoikayil, et al.
Published: (2013-09-01)

Differences in senescence of late Endothelial Progenitor Cells in non-smokers and smokers
by: Kumboyono Kumboyono, et al.
Published: (2021-06-01)

Velvet Antler Mobilizes Endothelial Progenitor Cells to Promote Angiogenesis and Repair Vascular Endothelial Injury in Rats Following Myocardial Infarction
by: Yanjun Li, et al.
Published: (2019-01-01)