Identification of Selective ERRγ Inverse Agonists

Identification of Selective ERRγ Inverse Agonists

GSK5182 (4) is currently one of the lead compounds for the development of estrogen-related receptor gamma (ERRγ) inverse agonists. Here, we report the design, synthesis, pharmacological and in vitro absorption, distribution, metabolism, excretion, toxicity (ADMET) properties of a series of compounds...

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Bibliographic Details
Main Authors: Jina Kim, Chun Young Im, Eun Kyung Yoo, Min Jung Ma, Sang-Bum Kim, Eunmi Hong, Jungwook Chin, Hayoung Hwang, Sungwoo Lee, Nam Doo Kim, Jae-Han Jeon, In-Kyu Lee, Yong Hyun Jeon, Hueng-Sik Choi, Seong Heon Kim, Sung Jin Cho
Format: Article
Language:English
Published: MDPI AG 2016-01-01
Series:Molecules
Subjects:
estrogen-related receptor gamma
inverse agonist
ADMET
GSK5182
Online Access:http://www.mdpi.com/1420-3049/21/1/80

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