Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis

Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis

BackgroundInflammasomes, which mediate maturation of interleukin-1β (IL-β) and interleukin-18 (IL-18) and lead to pyroptosis, have been linked to various autoimmune disorders. This study investigated whether they are involved in the pathogenesis of autoimmune thyroiditis (AIT).MethodsWe collected th...

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Bibliographic Details
Main Authors: Qingling Guo, Ying Wu, Yuanyuan Hou, Yongping Liu, Tingting Liu, Hao Zhang, Chenling Fan, Haixia Guan, Yushu Li, Zhongyan Shan, Weiping Teng
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
autoimmune thyroiditis
inflammasome
pyroptosis
interleukin-18 (IL-18)
absent in melanoma 2
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01197/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01197/full

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