Dichloroacetate Affects Mitochondrial Function and Stemness-Associated Properties in Pancreatic Cancer Cell Lines

Dichloroacetate Affects Mitochondrial Function and Stemness-Associated Properties in Pancreatic Cancer Cell Lines

Targeting metabolism represents a possible successful approach to treat cancer. Dichloroacetate (DCA) is a drug known to divert metabolism from anaerobic glycolysis to mitochondrial oxidative phosphorylation by stimulation of PDH. In this study, we investigated the response of two pancreatic cancer...

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Bibliographic Details
Main Authors: Tiziana Tataranni, Francesca Agriesti, Consiglia Pacelli, Vitalba Ruggieri, Ilaria Laurenzana, Carmela Mazzoccoli, Gerardo Della Sala, Concetta Panebianco, Valerio Pazienza, Nazzareno Capitanio, Claudia Piccoli
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cells
Subjects:
metabolism
mitochondria
cancer stem cells
Online Access:https://www.mdpi.com/2073-4409/8/5/478

Internet

https://www.mdpi.com/2073-4409/8/5/478

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