Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production

Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production

Imidazole propionate (ImP) produced by gut microbiota has been associated with type 2 diabetes. Here, the authors present crystal structures of the ImP biosynthesis enzyme urocanate reductase in four different states, providing molecular insights into its catalytic mechanism.

Bibliographic Details
Main Authors: Raminta Venskutonytė, Ara Koh, Olof Stenström, Muhammad Tanweer Khan, Annika Lundqvist, Mikael Akke, Fredrik Bäckhed, Karin Lindkvist-Petersson
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21548-y
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spelling doaj-51b05c6e4427465ea9174681f26b1d762021-03-11T11:31:37ZengNature Publishing GroupNature Communications2041-17232021-03-0112111110.1038/s41467-021-21548-yStructural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate productionRaminta Venskutonytė0Ara Koh1Olof Stenström2Muhammad Tanweer Khan3Annika Lundqvist4Mikael Akke5Fredrik Bäckhed6Karin Lindkvist-Petersson7Experimental Medical Science, Medical Structural Biology, BMC C13, Lund UniversityDepartment of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, University of GothenburgBiophysical Chemistry, Center for Molecular Protein Science, Department of Chemistry, Lund UniversityDepartment of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, University of GothenburgDepartment of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, University of GothenburgBiophysical Chemistry, Center for Molecular Protein Science, Department of Chemistry, Lund UniversityDepartment of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, University of GothenburgExperimental Medical Science, Medical Structural Biology, BMC C13, Lund UniversityImidazole propionate (ImP) produced by gut microbiota has been associated with type 2 diabetes. Here, the authors present crystal structures of the ImP biosynthesis enzyme urocanate reductase in four different states, providing molecular insights into its catalytic mechanism.https://doi.org/10.1038/s41467-021-21548-y
collection DOAJ
language English
format Article
sources DOAJ
author Raminta Venskutonytė
Ara Koh
Olof Stenström
Muhammad Tanweer Khan
Annika Lundqvist
Mikael Akke
Fredrik Bäckhed
Karin Lindkvist-Petersson
spellingShingle Raminta Venskutonytė
Ara Koh
Olof Stenström
Muhammad Tanweer Khan
Annika Lundqvist
Mikael Akke
Fredrik Bäckhed
Karin Lindkvist-Petersson
Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production
Nature Communications
author_facet Raminta Venskutonytė
Ara Koh
Olof Stenström
Muhammad Tanweer Khan
Annika Lundqvist
Mikael Akke
Fredrik Bäckhed
Karin Lindkvist-Petersson
author_sort Raminta Venskutonytė
title Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production
title_short Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production
title_full Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production
title_fullStr Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production
title_full_unstemmed Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production
title_sort structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-03-01
description Imidazole propionate (ImP) produced by gut microbiota has been associated with type 2 diabetes. Here, the authors present crystal structures of the ImP biosynthesis enzyme urocanate reductase in four different states, providing molecular insights into its catalytic mechanism.
url https://doi.org/10.1038/s41467-021-21548-y
work_keys_str_mv AT ramintavenskutonyte structuralcharacterizationofthemicrobialenzymeurocanatereductasemediatingimidazolepropionateproduction
AT arakoh structuralcharacterizationofthemicrobialenzymeurocanatereductasemediatingimidazolepropionateproduction
AT olofstenstrom structuralcharacterizationofthemicrobialenzymeurocanatereductasemediatingimidazolepropionateproduction
AT muhammadtanweerkhan structuralcharacterizationofthemicrobialenzymeurocanatereductasemediatingimidazolepropionateproduction
AT annikalundqvist structuralcharacterizationofthemicrobialenzymeurocanatereductasemediatingimidazolepropionateproduction
AT mikaelakke structuralcharacterizationofthemicrobialenzymeurocanatereductasemediatingimidazolepropionateproduction
AT fredrikbackhed structuralcharacterizationofthemicrobialenzymeurocanatereductasemediatingimidazolepropionateproduction
AT karinlindkvistpetersson structuralcharacterizationofthemicrobialenzymeurocanatereductasemediatingimidazolepropionateproduction
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