Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex.

Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex.

Deficiency of autophagy protein beclin 1 is implicated in tumorigenesis and neurodegenerative diseases, but the molecular mechanism remains elusive. Previous studies showed that Beclin 1 coordinates the assembly of multiple VPS34 complexes whose distinct phosphatidylinositol 3-kinase III (PI3K-III)...

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Bibliographic Details
Main Authors:	Nicole C McKnight, Yun Zhong, Mitchell S Wold, Shiaoching Gong, Greg R Phillips, Zhixun Dou, Yanxiang Zhao, Nathaniel Heintz, Wei-Xing Zong, Zhenyu Yue
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-10-01
Series:	PLoS Genetics
Online Access:	http://europepmc.org/articles/PMC4183436?pdf=render

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