Tyrosine and aurora kinase inhibitors diminish transport function of multidrug resistance-associated protein (MRP) 4 and breast cancer resistance protein (BCRP)

Tyrosine and aurora kinase inhibitors diminish transport function of multidrug resistance-associated protein (MRP) 4 and breast cancer resistance protein (BCRP)

Tyrosine and aurora kinases are important effectors in signal transduction pathways that are often involved in aberrant cancer cell growth. Tyrosine (TKI) and aurora (AKI) kinase inhibitors are anti-cancer agents specifically designed to target such signaling pathways through TKI/AKI binding to the...

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Bibliographic Details
Main Authors: Rhiannon N. Hardwick, Marina Snellings, Brian C. Ferslew, Yang Lu, Kim L.R. Browuer
Format: Article
Language:English
Published: International Association of Physical Chemists (IAPC) 2016-12-01
Series:ADMET and DMPK
Subjects:
ABC transporters, transport inhibition
Online Access:http://pub.iapchem.org/ojs/index.php/admet/article/view/322

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