Autophagy regulates lipid metabolism through selective turnover of NCoR1
Defective autophagy has been associated with metabolic disorders. Here Saito et al. show that autophagy promotes the selective degradation of NCoR1, a repressor of lipid metabolism regulator PPARα, in response to starvation, and thus induces the expression of enzymes involved in lipid oxidation and...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-08829-3 |
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doaj-51a6699afdbe409189590eaa1356ad952021-05-11T11:27:12ZengNature Publishing GroupNature Communications2041-17232019-04-0110111610.1038/s41467-019-08829-3Autophagy regulates lipid metabolism through selective turnover of NCoR1Tetsuya Saito0Akiko Kuma1Yuki Sugiura2Yoshinobu Ichimura3Miki Obata4Hiroshi Kitamura5Shujiro Okuda6Hyeon-Cheol Lee7Kazutaka Ikeda8Yumi Kanegae9Izumu Saito10Johan Auwerx11Hozumi Motohashi12Makoto Suematsu13Tomoyoshi Soga14Takehiko Yokomizo15Satoshi Waguri16Noboru Mizushima17Masaaki Komatsu18Department of Biochemistry, Niigata University Graduate School of Medical and Dental SciencesDepartment of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The University of TokyoJapan Science and Technology Agency, PRESTODepartment of Biochemistry, Niigata University Graduate School of Medical and Dental SciencesDepartment of Biochemistry, Niigata University Graduate School of Medical and Dental SciencesDepartment of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku UniversityBioinformatics Laboratory, Niigata University Graduate School of Medical and Dental SciencesDepartment of Biochemistry, Juntendo University Graduate School of MedicineLaboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS)Core Research Facilities of Basic Science (Molecular Genetics), Research Center for Medical Science, Jikei University School of MedicineLaboratory of Molecular Genetics, Institute of Medical Science, The University of TokyoLaboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL)Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku UniversityDepartment of Biochemistry, Keio University School of MedicineInstitute for Advanced Biosciences, Keio UniversityDepartment of Biochemistry, Juntendo University Graduate School of MedicineDepartment of Anatomy and Histology, Fukushima Medical University School of MedicineDepartment of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The University of TokyoDepartment of Biochemistry, Niigata University Graduate School of Medical and Dental SciencesDefective autophagy has been associated with metabolic disorders. Here Saito et al. show that autophagy promotes the selective degradation of NCoR1, a repressor of lipid metabolism regulator PPARα, in response to starvation, and thus induces the expression of enzymes involved in lipid oxidation and the production of ketone bodies.https://doi.org/10.1038/s41467-019-08829-3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Tetsuya Saito Akiko Kuma Yuki Sugiura Yoshinobu Ichimura Miki Obata Hiroshi Kitamura Shujiro Okuda Hyeon-Cheol Lee Kazutaka Ikeda Yumi Kanegae Izumu Saito Johan Auwerx Hozumi Motohashi Makoto Suematsu Tomoyoshi Soga Takehiko Yokomizo Satoshi Waguri Noboru Mizushima Masaaki Komatsu |
| spellingShingle |
Tetsuya Saito Akiko Kuma Yuki Sugiura Yoshinobu Ichimura Miki Obata Hiroshi Kitamura Shujiro Okuda Hyeon-Cheol Lee Kazutaka Ikeda Yumi Kanegae Izumu Saito Johan Auwerx Hozumi Motohashi Makoto Suematsu Tomoyoshi Soga Takehiko Yokomizo Satoshi Waguri Noboru Mizushima Masaaki Komatsu Autophagy regulates lipid metabolism through selective turnover of NCoR1 Nature Communications |
| author_facet |
Tetsuya Saito Akiko Kuma Yuki Sugiura Yoshinobu Ichimura Miki Obata Hiroshi Kitamura Shujiro Okuda Hyeon-Cheol Lee Kazutaka Ikeda Yumi Kanegae Izumu Saito Johan Auwerx Hozumi Motohashi Makoto Suematsu Tomoyoshi Soga Takehiko Yokomizo Satoshi Waguri Noboru Mizushima Masaaki Komatsu |
| author_sort |
Tetsuya Saito |
| title |
Autophagy regulates lipid metabolism through selective turnover of NCoR1 |
| title_short |
Autophagy regulates lipid metabolism through selective turnover of NCoR1 |
| title_full |
Autophagy regulates lipid metabolism through selective turnover of NCoR1 |
| title_fullStr |
Autophagy regulates lipid metabolism through selective turnover of NCoR1 |
| title_full_unstemmed |
Autophagy regulates lipid metabolism through selective turnover of NCoR1 |
| title_sort |
autophagy regulates lipid metabolism through selective turnover of ncor1 |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-04-01 |
| description |
Defective autophagy has been associated with metabolic disorders. Here Saito et al. show that autophagy promotes the selective degradation of NCoR1, a repressor of lipid metabolism regulator PPARα, in response to starvation, and thus induces the expression of enzymes involved in lipid oxidation and the production of ketone bodies. |
| url |
https://doi.org/10.1038/s41467-019-08829-3 |
| work_keys_str_mv |
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