Clinical study on botulinum toxin A injections for blepharospasm

AIM: To observe the efficacy of using botulinum toxin A in the treatment of blepharospasm.<p>METHODS:Totally 113 patients with blepharospasm were managed with a local injection of botulinum toxin A, and the therapeutic effect was evaluated.<p>RESULTS:Fifty-nine cases(52.2%)had a complete...

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Bibliographic Details
Main Authors: Yong-Hong Jiao, Yi-Di Wang, Zhe Pan
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2014-07-01
Series:Guoji Yanke Zazhi
Subjects:
Online Access:http://www.ies.net.cn/cn_publish/2014/7/201407053.pdf
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Summary:AIM: To observe the efficacy of using botulinum toxin A in the treatment of blepharospasm.<p>METHODS:Totally 113 patients with blepharospasm were managed with a local injection of botulinum toxin A, and the therapeutic effect was evaluated.<p>RESULTS:Fifty-nine cases(52.2%)had a complete remission of symptoms, 49 patients(43.4%)presented with obvious relieved spasm, 4 cases(3.5%)were partially relieved and the 1 patient(0.9%)remained unchanged. The total effective rate was 99.1%. The time of beginning effect was 1-14d. The recover time was mostly in 14d. The average of therapeutic effect lasted 1-9mo. Adverse reactions such as mild palpebra dysraphism, palpebra ptosis and local subcutaneous blood stasis were found in 23 patients, and the symptoms disappeared in 2-4wk.<p>CONCLUSION:Botulinum toxin A can effectively control medium and severe blepharospasm by injecting a little dose on local muscle.
ISSN:1672-5123
1672-5123