Bifurcations and Dynamics of the Rb-E2F Pathway Involving miR449

We focused on the gene regulative network involving Rb-E2F pathway and microRNAs (miR449) and studied the influence of time delay on the dynamical behaviors of Rb-E2F pathway by using Hopf bifurcation theory. It is shown that under certain assumptions the steady state of the delay model is asymptoti...

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Bibliographic Details
Main Authors: Lingling Li, Jianwei Shen
Format: Article
Language:English
Published: Hindawi-Wiley 2017-01-01
Series:Complexity
Online Access:http://dx.doi.org/10.1155/2017/1409865