GFP-Fragment Reassembly Screens for the Functional Characterization of Variants of Uncertain Significance in Protein Interaction Domains of the <i>BRCA1</i> and <i>BRCA2</i> Genes

GFP-Fragment Reassembly Screens for the Functional Characterization of Variants of Uncertain Significance in Protein Interaction Domains of the <i>BRCA1</i> and <i>BRCA2</i> Genes

Genetic testing for <i>BRCA1</i> and <i>BRCA2</i> genes has led to the identification of many unique variants of uncertain significance (VUS). Multifactorial likelihood models that predict the odds ratio for VUS in favor or against cancer causality, have been developed, but t...

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Bibliographic Details
Main Authors: Laura Caleca, Mara Colombo, Thomas van Overeem Hansen, Conxi Lázaro, Siranoush Manoukian, Michael T. Parsons, Amanda B. Spurdle, Paolo Radice
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cancers
Subjects:
hereditary breast/ovarian cancer
<i>BRCA1</i>
<i>BRCA2</i>
variant of uncertain significance
functional assays
protein-protein interaction
Online Access:https://www.mdpi.com/2072-6694/11/2/151

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