Impiego di tramadolo nelle diverse patologie dolorose

Pain represents a major health problem that afflicts a significant number of patients, resulting in personal suffering, reduced productivity and substantial health care costs, specially in chronic conditions. Chronic pain, such as low back pain, osteoarthritis, neuropathic and oncologic pain, requir...

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Main Author: Orietta Zaniolo
Format: Article
Language:English
Published: SEEd Medical Publishers 2005-12-01
Series:Farmeconomia: Health Economics and Therapeutic Pathways
Subjects:
Online Access:https://journals.seedmedicalpublishers.com/index.php/FE/article/view/853
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spelling doaj-5196378eb4cd4c8d93c0803af830d5842020-11-25T00:12:40ZengSEEd Medical PublishersFarmeconomia: Health Economics and Therapeutic Pathways2240-256X2005-12-016438539610.7175/fe.v6i4.853798Impiego di tramadolo nelle diverse patologie doloroseOrietta Zaniolo0dvanced Research Srl

Pain represents a major health problem that afflicts a significant number of patients, resulting in personal suffering, reduced productivity and substantial health care costs, specially in chronic conditions. Chronic pain, such as low back pain, osteoarthritis, neuropathic and oncologic pain, requires a global management based on clinical evaluation, defining of the adequate therapeutic strategy and assiduous cares. Generally, patients with chronic pain need two different analgesic formulation: one at fixed doses and prolonged duration of action for control of baseline pain and one fast-release drug for treatment of breakthrough pain. Main guidelines recommend use of the same active principle for both these formulations. Tramadol, a dual action analgesic agent, used for controlling moderate to severe pain control in acute and chronic diseases, is available in several different oral formulations. This is important because, apart from efficacy and tolerability, that are the most important criteria to evaluate a therapy, the choice of a formulation with an uncomplicated dosing regimen can increase compliance and, consequently, clinical results, and ameliorate patient quality of life. For the treatment of chronic pain, the appropriate analgesic dosage can be achieved through a gradual titration: this permits to minimize adverse effects and cost of therapy.With tramadol this action can be realized with 50 mg extended-release capsules, that represent the minimal effective dose. When adequate pain relief is obtained, it’s possible to reduce frequency and complexity of dosing regimen using a new once-daily tablet of tramadol. Fast-release orodispersible tramadol tablet, with its practical advantage (rapid disintegration in the mouth without need of water), can be used for the control of breakthrough and acute pain. The cost of treatment with tramadol results relatively low, also when two daily episodes of breakthrough pain are considered.https://journals.seedmedicalpublishers.com/index.php/FE/article/view/853tramadolchronic paincost of treatmentcompliance
collection DOAJ
language English
format Article
sources DOAJ
author Orietta Zaniolo
spellingShingle Orietta Zaniolo
Impiego di tramadolo nelle diverse patologie dolorose
Farmeconomia: Health Economics and Therapeutic Pathways
tramadol
chronic pain
cost of treatment
compliance
author_facet Orietta Zaniolo
author_sort Orietta Zaniolo
title Impiego di tramadolo nelle diverse patologie dolorose
title_short Impiego di tramadolo nelle diverse patologie dolorose
title_full Impiego di tramadolo nelle diverse patologie dolorose
title_fullStr Impiego di tramadolo nelle diverse patologie dolorose
title_full_unstemmed Impiego di tramadolo nelle diverse patologie dolorose
title_sort impiego di tramadolo nelle diverse patologie dolorose
publisher SEEd Medical Publishers
series Farmeconomia: Health Economics and Therapeutic Pathways
issn 2240-256X
publishDate 2005-12-01
description Pain represents a major health problem that afflicts a significant number of patients, resulting in personal suffering, reduced productivity and substantial health care costs, specially in chronic conditions. Chronic pain, such as low back pain, osteoarthritis, neuropathic and oncologic pain, requires a global management based on clinical evaluation, defining of the adequate therapeutic strategy and assiduous cares. Generally, patients with chronic pain need two different analgesic formulation: one at fixed doses and prolonged duration of action for control of baseline pain and one fast-release drug for treatment of breakthrough pain. Main guidelines recommend use of the same active principle for both these formulations. Tramadol, a dual action analgesic agent, used for controlling moderate to severe pain control in acute and chronic diseases, is available in several different oral formulations. This is important because, apart from efficacy and tolerability, that are the most important criteria to evaluate a therapy, the choice of a formulation with an uncomplicated dosing regimen can increase compliance and, consequently, clinical results, and ameliorate patient quality of life. For the treatment of chronic pain, the appropriate analgesic dosage can be achieved through a gradual titration: this permits to minimize adverse effects and cost of therapy.With tramadol this action can be realized with 50 mg extended-release capsules, that represent the minimal effective dose. When adequate pain relief is obtained, it’s possible to reduce frequency and complexity of dosing regimen using a new once-daily tablet of tramadol. Fast-release orodispersible tramadol tablet, with its practical advantage (rapid disintegration in the mouth without need of water), can be used for the control of breakthrough and acute pain. The cost of treatment with tramadol results relatively low, also when two daily episodes of breakthrough pain are considered.
topic tramadol
chronic pain
cost of treatment
compliance
url https://journals.seedmedicalpublishers.com/index.php/FE/article/view/853
work_keys_str_mv AT oriettazaniolo impiegoditramadolonellediversepatologiedolorose
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