Novel Anti-Interleukin-1β Therapy Preserves Retinal Integrity: A Longitudinal Investigation Using OCT Imaging and Automated Retinal Segmentation in Small Rodents

Novel Anti-Interleukin-1β Therapy Preserves Retinal Integrity: A Longitudinal Investigation Using OCT Imaging and Automated Retinal Segmentation in Small Rodents

Retinopathy of prematurity (ROP) is the leading cause of blindness in neonates. Inflammation, in particular interleukin-1β (IL-1β), is increased in early stages of the disorder, and contributes to inner and outer retinal vasoobliteration in the oxygen-induced retinopathy (OIR) model of ROP. A small...

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Bibliographic Details
Main Authors: Diane N. Sayah, Tianwei E. Zhou, Samy Omri, Javier Mazzaferri, Christiane Quiniou, Maëlle Wirth, France Côté, Rabah Dabouz, Michel Desjarlais, Santiago Costantino, Sylvain Chemtob
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
rytvela
kineret
anti-interleukin-1β
therapy
oxygen-induced retinopathy
retina
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00296/full

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