New Insights into Human Cytomegalovirus pUL52 Structure

New Insights into Human Cytomegalovirus pUL52 Structure

Human cytomegalovirus (HCMV) can cause serious diseases in immunocompromised patients. Current antiviral inhibitors all target the viral DNA polymerase. They have adverse effects, and prolonged treatment can select for drug resistance mutations. Thus, new drugs targeting other stages of replication...

Full description

Bibliographic Details
Main Authors:	Clotilde Muller, Sophie Alain, Claire Gourin, Thomas F. Baumert, Gaëtan Ligat, Sébastien Hantz
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Series:	Viruses
Subjects:	human cytomegalovirus terminase DNA-packaging pUL52 viral targets
Online Access:	https://www.mdpi.com/1999-4915/13/8/1638

Similar Items

Cytomégalovirus humain, mutations de résistance et nouvelles cibles thérapeutiques
by: Ligat, Gaëtan
Published: (2017)

Functional Relevance of the Interaction between Human Cyclins and the Cytomegalovirus-Encoded CDK-Like Protein Kinase pUL97
by: Martin Schütz, et al.
Published: (2021-06-01)

Hinge Region in DNA Packaging Terminase pUL15 of Herpes Simplex Virus: A Potential Allosteric Target for Antiviral Drugs
by: Lana F. Thaljeh, et al.
Published: (2019-10-01)

Characterization of the Transcripts that Encode pUL138, a Latency Determinant, During Human Cytomegalovirus Infection
by: Grainger, Lora Ann
Published: (2010)

Changes in subcellular localization reveal interactions between human cytomegalovirus terminase subunits
by: Wang Jian Ben, et al.
Published: (2012-12-01)

Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97
by: Jens Milbradt, et al.
Published: (2018-01-01)

The Cyclin-Dependent Kinase Ortholog pUL97 of Human Cytomegalovirus Interacts with Cyclins
by: Laura Graf, et al.
Published: (2013-12-01)

Phenotypical Characterization of the Nuclear Egress of Recombinant Cytomegaloviruses Reveals Defective Replication upon ORF-UL50 Deletion but Not pUL50 Phosphosite Mutation
by: Sigrun Häge, et al.
Published: (2021-01-01)

Structures and Divergent Mechanisms in Capsid Maturation and Stabilization Following Genome Packaging of Human Cytomegalovirus and Herpesviruses
by: Clotilde Muller, et al.
Published: (2021-02-01)

Strukturelle Einblicke in die Funktionalität des Terminase-Proteins pUL89, eine Untereinheit des Nanomotors des humanen Cytomegalievirus (HCMV).
by: Theiß, Janine
Published: (2020)

Proteomic Interaction Patterns between Human Cyclins, the Cyclin-Dependent Kinase Ortholog pUL97 and Additional Cytomegalovirus Proteins
by: Mirjam Steingruber, et al.
Published: (2016-08-01)

The Cytomegalovirus Protein Kinase pUL97: Host Interactions, Regulatory Mechanisms and Antiviral Drug Targeting
by: Mirjam Steingruber, et al.
Published: (2020-04-01)

Cytomégalovirus Humain : variabilité, Recombinaison et Protéine pUL40
by: Faure-Della Corte, Muriel
Published: (2010)

The Interaction between Cyclin B1 and Cytomegalovirus Protein Kinase pUL97 is Determined by an Active Kinase Domain
by: Mirjam Steingruber, et al.
Published: (2015-08-01)

The HSV1 Tail-Anchored Membrane Protein pUL34 Contains a Basic Motif That Supports Active Transport to the Inner Nuclear Membrane Prior to Formation of the Nuclear Egress Complex
by: Christina Funk, et al.
Published: (2021-08-01)

Venture from the Interior—Herpesvirus pUL31 Escorts Capsids from Nucleoplasmic Replication Compartments to Sites of Primary Envelopment at the Inner Nuclear Membrane
by: Susanne M. Bailer
Published: (2017-11-01)

The Role of pUL138 In HCMV Persistence
by: Petrucelli, Alexius
Published: (2011)

Human Cytomegalovirus Nuclear Egress Proteins Ectopically Expressed in the Heterologous Environment of Plant Cells are Strictly Targeted to the Nuclear Envelope
by: Christian E. Lamm, et al.
Published: (2016-03-01)

Inhibition of cytomegalovirus genome maturation by the halogenated benzimidazoles
by: Sauer, Anne
Published: (2010)

Characterization of the transcripts of human cytomegalovirus UL144
by: Sun Zhengrong, et al.
Published: (2011-06-01)

Protein-DNA Interactions of pUL34, an Essential Human Cytomegalovirus DNA-Binding Protein
by: Slayton, Mark D.
Published: (2018)

Functional Domains of the Herpes Simplex Virus Type 1 Tegument Protein pUL37: The Amino Terminus is Dispensable for Virus Replication in Tissue Culture
by: Peter Grzesik, et al.
Published: (2019-09-01)

Identification of a short sequence in the HCMV terminase pUL56 essential for interaction with pUL89 subunit
by: G. Ligat, et al.
Published: (2017-08-01)

Architecture of the herpesvirus genome-packaging complex and implications for DNA translocation
by: Yunxiang Yang, et al.
Published: (2020-04-01)

UL146 variability among clinical isolates of Human Cytomegalovirus from Japan
by: Francisco Aguayo, et al.
Published: (2010-01-01)

Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex
by: Benjamin G Butt, et al.
Published: (2020-05-01)

Identification of Amino Acids Essential for Viral Replication in the HCMV Helicase-Primase Complex
by: Gaetan Ligat, et al.
Published: (2018-10-01)

Identification of UL69 Gene and Protein in Cytomegalovirus-Transformed Human Mammary Epithelial Cells
by: Sandy Haidar Ahmad, et al.
Published: (2021-04-01)

The Role of the Human Cytomegalovirus <i>UL133-UL138</i> Gene Locus in Latency and Reactivation
by: Luwanika Mlera, et al.
Published: (2020-07-01)

Kvalitativ studie om programledarnas upplevelser om behandlingsprogrammet PULS
by: Lüdge, Mattias, et al.
Published: (2021)

Enteric Chromosomal Islands: DNA Packaging Specificity and Role of λ-like Helper Phage Terminase
by: Feiss, M., et al.
Published: (2022)

Intracellular Trafficking of the Human Cytomegalovirus-Encoded 7-trans-Membrane Protein Homologs pUS27 and pUL78 during Viral Infection: A Comparative Analysis
by: Ina Niemann, et al.
Published: (2014-02-01)

Human Cytomegalovirus UL34 Early and late Proteins Are Essential for Viral Replication
by: Rico Rana, et al.
Published: (2014-01-01)

The Bacteriophage lambdaDNA packaging enzyme: Identification of four structural domains of the gpNu1 subunit using limited proteolysis
by: PAMELA ARAYA, et al.
Published: (2001-01-01)

Terminase Large Subunit Provides a New Drug Target for Herpesvirus Treatment
by: Linlin Yang, et al.
Published: (2019-03-01)

IC-påverkan av elektromagnetisk puls
by: Lindskog, Claes
Published: (2008)

Étude du mécanisme moléculaire de résistance antivirale du cytomégalovirus humain et des mutations de l’ADN polymérase UL54 qui lui sont associées
by: Allaire, Andréa
Published: (2017)

Sumoylation of the Carboxy-Terminal of Human Cytomegalovirus DNA Polymerase Processivity Factor UL44 Attenuates Viral DNA Replication
by: Jun Chen, et al.
Published: (2021-04-01)

Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and UL138 Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways
by: Meaghan H. Hancock, et al.
Published: (2020-08-01)

<i>Divide et impera</i>: An <i>In Silico</i> Screening Targeting HCMV ppUL44 Processivity Factor Homodimerization Identifies Small Molecules Inhibiting Viral Replication
by: Hanieh Ghassabian, et al.
Published: (2021-05-01)