Harnessing CD16-Mediated NK Cell Functions to Enhance Therapeutic Efficacy of Tumor-Targeting mAbs

Harnessing CD16-Mediated NK Cell Functions to Enhance Therapeutic Efficacy of Tumor-Targeting mAbs

Natural killer (NK) cells hold a pivotal role in tumor-targeting monoclonal antibody (mAb)-based activity due to the expression of CD16, the low-affinity receptor for IgG. Indeed, beyond exerting cytotoxic function, activated NK cells also produce an array of cytokines and chemokines, through which...

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Bibliographic Details
Main Authors: Cristina Capuano, Chiara Pighi, Simone Battella, Davide De Federicis, Ricciarda Galandrini, Gabriella Palmieri
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
tumor-targeting mAb
memory NK cells
vaccinal effect
IFNγ
CD16
ADCC
Online Access:https://www.mdpi.com/2072-6694/13/10/2500

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