Recombinant immunotoxin anti-c-Met/PE38KDEL inhibits proliferation and promotes apoptosis of gastric cancer cells

Recombinant immunotoxin anti-c-Met/PE38KDEL inhibits proliferation and promotes apoptosis of gastric cancer cells

<p>Abstract</p> <p>Background</p> <p>Our study aims to evaluate the anti-growth effects of recombinant immunotoxin (IT) anti-c-Met/PE38KDEL on gastric cancer cells, and its mechnisms.</p> <p>Methods</p> <p>Gastric cancer cells were treated with i...

Full description

Bibliographic Details
Main Authors:	Hua Zhang, Nan Cai, Min Feng, Juan Zhu, Wei Xu, Qing Feng, Zheng Liu
Format:	Article
Language:	English
Published:	BMC 2011-07-01
Series:	Journal of Experimental & Clinical Cancer Research
Online Access:	http://www.jeccr.com/content/30/1/67

Similar Items

Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors.
by: Xin Yu, et al.
Published: (2019-01-01)

Study on the targeted therapy of oral squamous cell carcinoma with a plasmid expressing PE38KDEL toxin under control of the SERPINB3 promoter
by: Jiang Wu, et al.
Published: (2020-03-01)

Modeling Recombinant Immunotoxin Efficacies in Solid Tumors

Development of Recombinant Immunotoxins for Hairy Cell Leukemia
by: Robert J. Kreitman, et al.
Published: (2020-08-01)

Mesothelin-Targeted Recombinant Immunotoxins for Solid Tumors
by: Brendan L. Hagerty, et al.
Published: (2020-06-01)

Clinical targeting recombinant immunotoxins for cancer therapy
by: Li M, et al.
Published: (2017-07-01)

α-MSH-PE38KDEL Kills Melanoma Cells via Modulating Erk1/2/MITF/TYR Signaling in an MC1R-Dependent Manner
by: Liu X, et al.
Published: (2020-12-01)

Antiviral Immunotoxin Against Bovine herpesvirus-1: Targeted Inhibition of Viral Replication and Apoptosis of Infected Cell
by: Jian Xu, et al.
Published: (2018-04-01)

Towards Engineering Novel PE-Based Immunotoxins by Targeting Them to the Nucleus
by: Marta Borowiec, et al.
Published: (2016-11-01)

Construction, Expression, and Characterization of a Recombinant Immunotoxin Targeting EpCAM
by: Minghua Lv, et al.
Published: (2015-01-01)

Biochemical characterisation of the human KDEL receptor
by: Scheel, Andreas
Published: (1998)

Hosts for Hostile Protein Production: The Challenge of Recombinant Immunotoxin Expression
by: Stefania Zuppone, et al.
Published: (2019-05-01)

The Function of KDEL Receptors as UPR Genes in Disease
by: Emily S. Wires, et al.
Published: (2021-05-01)

Evaluation of Hydra HALT-1 as a toxin moiety for recombinant immunotoxin
by: William F. Jiemy, et al.
Published: (2020-06-01)

Recombinant immunotoxins development for HER2-based targeted cancer therapies
by: Reza Mahmoudi, et al.
Published: (2021-09-01)

Synergistic anticancer effects of the 9.2.27PE immunotoxin and ABT-737 in melanoma.
by: Karianne Risberg, et al.
Published: (2011-01-01)

Gramicidin inhibits human gastric cancer cell proliferation, cell cycle and induced apoptosis
by: Tingting Chen, et al.
Published: (2019-11-01)

Recombinant engineering of single-chain antibody-RNase immunotoxin for cancer cell targeting
by: Pin-Chen Chen, et al.
Published: (2019)

Evaluating the influence of common antibiotics on the efficacy of a recombinant immunotoxin in tissue culture
by: Yuyi Zhu, et al.
Published: (2019-05-01)

Recombinant Immunotoxin Therapy of Glioblastoma: Smart Design, Key Findings, and Specific Challenges
by: Shaowei Zhu, et al.
Published: (2017-01-01)

Optimization of Chemically Defined Cell Culture Media for Recombinant ONTAK Immunotoxin Production
by: Mohammad Heydari, et al.
Published: (2014-10-01)

KDEL Receptors Assist Dengue Virus Exit from the Endoplasmic Reticulum
by: Ming Yuan Li, et al.
Published: (2015-03-01)

Immunotoxins: The Role of the Toxin
by: David FitzGerald, et al.
Published: (2013-08-01)

TFF1 inhibits proliferation and induces apoptosis of gastric cancer cells in vitro
by: Yanli Ge, et al.
Published: (2012-05-01)

The Functional Roles of KDEL receptor involved in JEV infection cycle
by: Ci Wei Chao, et al.
Published: (2018)

Drosophila KDEL receptor function in the embryonic salivary gland and epidermis.
by: Elliott W Abrams, et al.
Published: (2013-01-01)

Prohibitin: A Novel Molecular Player in KDEL Receptor Signalling
by: Monica Giannotta, et al.
Published: (2015-01-01)

Effect of ANLN Gene Silencing on Invasion, Migration, Proliferation and Apoptosis of Gastric Cancer Cells
by: SUN Hui, et al.
Published: (2019-10-01)

Interactions Between Pseudomonas Immunotoxins and the Plasma Membrane: Implications for CAT-8015 Immunotoxin Therapy
by: Monika Bokori-Brown, et al.
Published: (2018-11-01)

Foretinib Inhibits Cancer Stemness and Gastric Cancer Cell Proliferation by Decreasing CD44 and c-MET Signaling
by: Sohn SH, et al.
Published: (2020-02-01)

Site-Specific PEGylation of Recombinant Immunotoxin DAB389IL-2: Structural and Functional Assessment
by: Nasrin Zarkar, et al.
Published: (2019-11-01)

Cell-type-specific differences in KDEL receptor clustering in mammalian cells.
by: Achim Bauer, et al.
Published: (2020-01-01)

Genetic and biochemical interactions of the S7 ATPase of the 26S proteasome and the KDEL receptor
by: Saleh, Sherif Aly Abdelgawad
Published: (2002)

EGFR-Targeted Immunotoxin Exerts Antitumor Effects on Esophageal Cancers by Increasing ROS Accumulation and Inducing Apoptosis via Inhibition of the Nrf2-Keap1 Pathway
by: Yun Yang, et al.
Published: (2018-01-01)

Bouganin, an Attractive Weapon for Immunotoxins
by: Massimo Bortolotti, et al.
Published: (2018-08-01)

Immunotoxin Therapy for Lung Cancer
by: Li-Yi Xie, et al.
Published: (2017-01-01)

Chinese Propolis Inhibits the Proliferation of Human Gastric Cancer Cells by Inducing Apoptosis and Cell Cycle Arrest
by: Xia-sen Jiang, et al.
Published: (2020-01-01)

A Single-Domain Antibody-Based Anti-PSMA Recombinant Immunotoxin Exhibits Specificity and Efficacy for Prostate Cancer Therapy
by: Yutong Xing, et al.
Published: (2021-05-01)

A Human Recombinant Autoantibody-Based Immunotoxin Specific for the Fetal Acetylcholine Receptor Inhibits Rhabdomyosarcoma Growth In Vitro and in a Murine Transplantation Model
by: S. Gattenlöhner, et al.
Published: (2010-01-01)

Evaluation of the PEΔIII-LC3-KDEL3 Chimeric Protein of Entamoeba histolytica-Lectin as a Vaccine Candidate against Amebic Liver Abscess
by: Sandra L. Martínez-Hernández, et al.
Published: (2021-01-01)