Cardiovascular Pharmacology of Sinomenine: The Mechanical and Electropharmacological Actions

Sinomenine is one of the alkaloids extracted from Chinese medical plant, Sinomenium acutum Rehder et Wilson. Sinomenine has been used for Rheumatoid arthritis as an anti-inflammatory and immunomodulative drugs. We have so far been investigated the cardiovascular pharmacological actions of sinomenine...

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Main Authors: Seiichiro Nishida, Hiroyasu Satoh
Format: Article
Language:English
Published: AboutScience Srl 2007-01-01
Series:Drug Target Insights
Online Access:https://doi.org/10.1177/117739280700200015
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spelling doaj-516cf877e83649a58f5573991852ed672020-11-25T02:30:09ZengAboutScience SrlDrug Target Insights1177-39282007-01-01210.1177/117739280700200015Cardiovascular Pharmacology of Sinomenine: The Mechanical and Electropharmacological ActionsSeiichiro Nishida0Hiroyasu Satoh1Department of Pharmacology, Division of Traditional Medicine, Nara Medical University, Kashihara, Nara 634-8521, JapanDepartment of Pharmacology, Division of Traditional Medicine, Nara Medical University, Kashihara, Nara 634-8521, JapanSinomenine is one of the alkaloids extracted from Chinese medical plant, Sinomenium acutum Rehder et Wilson. Sinomenine has been used for Rheumatoid arthritis as an anti-inflammatory and immunomodulative drugs. We have so far been investigated the cardiovascular pharmacological actions of sinomenine. Sinomenine dilated NE (5 μM)-, KCl (60 mM)- and PDB (300 nM)-induced vasoconstrictions. The pretreatment with nicardipine (0.1 μM), staurosporine (30 nM), L-NMMA (100 μM), indomethacin (10 μM) or propranolol significantly attenuated the sinomenine-induced vasorelaxation. Therefore, these results indicate that sinomenine causes the vasorelaxation by the involvement with the inhibitions of Ca 2+ current (I Ca ) and PK-C, β-adrenoceptor stimulation, and the activation of NO and PGI 2 syntheses in endothelium. On the other hand, in the ventricular cardiomyocytes of guinea pig, sinomenine inhibits I Ca and simultaneously decreases the delayed rectifier K + current (I K ), resulting in the prolongation of action potential duration. Sinomenine also suppresses the dysrhysmias induced by triggered activities under the Ca 2+ overload condition. Therefore, sinomenine may be expected as one of effective therapeutic drugs for heart failure and dysrhythmias, and may maintain the cardiovascular functions due to modulation of cardiac ionic channels and blood vessels.https://doi.org/10.1177/117739280700200015
collection DOAJ
language English
format Article
sources DOAJ
author Seiichiro Nishida
Hiroyasu Satoh
spellingShingle Seiichiro Nishida
Hiroyasu Satoh
Cardiovascular Pharmacology of Sinomenine: The Mechanical and Electropharmacological Actions
Drug Target Insights
author_facet Seiichiro Nishida
Hiroyasu Satoh
author_sort Seiichiro Nishida
title Cardiovascular Pharmacology of Sinomenine: The Mechanical and Electropharmacological Actions
title_short Cardiovascular Pharmacology of Sinomenine: The Mechanical and Electropharmacological Actions
title_full Cardiovascular Pharmacology of Sinomenine: The Mechanical and Electropharmacological Actions
title_fullStr Cardiovascular Pharmacology of Sinomenine: The Mechanical and Electropharmacological Actions
title_full_unstemmed Cardiovascular Pharmacology of Sinomenine: The Mechanical and Electropharmacological Actions
title_sort cardiovascular pharmacology of sinomenine: the mechanical and electropharmacological actions
publisher AboutScience Srl
series Drug Target Insights
issn 1177-3928
publishDate 2007-01-01
description Sinomenine is one of the alkaloids extracted from Chinese medical plant, Sinomenium acutum Rehder et Wilson. Sinomenine has been used for Rheumatoid arthritis as an anti-inflammatory and immunomodulative drugs. We have so far been investigated the cardiovascular pharmacological actions of sinomenine. Sinomenine dilated NE (5 μM)-, KCl (60 mM)- and PDB (300 nM)-induced vasoconstrictions. The pretreatment with nicardipine (0.1 μM), staurosporine (30 nM), L-NMMA (100 μM), indomethacin (10 μM) or propranolol significantly attenuated the sinomenine-induced vasorelaxation. Therefore, these results indicate that sinomenine causes the vasorelaxation by the involvement with the inhibitions of Ca 2+ current (I Ca ) and PK-C, β-adrenoceptor stimulation, and the activation of NO and PGI 2 syntheses in endothelium. On the other hand, in the ventricular cardiomyocytes of guinea pig, sinomenine inhibits I Ca and simultaneously decreases the delayed rectifier K + current (I K ), resulting in the prolongation of action potential duration. Sinomenine also suppresses the dysrhysmias induced by triggered activities under the Ca 2+ overload condition. Therefore, sinomenine may be expected as one of effective therapeutic drugs for heart failure and dysrhythmias, and may maintain the cardiovascular functions due to modulation of cardiac ionic channels and blood vessels.
url https://doi.org/10.1177/117739280700200015
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AT hiroyasusatoh cardiovascularpharmacologyofsinomeninethemechanicalandelectropharmacologicalactions
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