Preventing or attenuating amphotericin B nephrotoxicity with dopamine receptor agonists: a literature review

Nephrotoxicity is generally considered as the most clinically significant and dose-limiting adverse reaction of amphotericin B. Currently, only the clinical effectiveness of salt loading and administering lipid formulations of amphotericin B have been clearly demonstrated to prevent its nephrotoxici...

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Main Authors: Iman Karimzadeh, Hossein Khalili, Mohammad Mahdi Sagheb
Format: Article
Language:English
Published: Shiraz University of Medical Sciences 2015-09-01
Series:Trends in Pharmaceutical Sciences
Online Access:https://tips.sums.ac.ir/article_42163_857ba62c332b20974a84f35db067d48c.pdf
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spelling doaj-5169d27b8f4e4cfc98158958667f37ee2021-07-14T06:10:36ZengShiraz University of Medical SciencesTrends in Pharmaceutical Sciences2423-56522015-09-011312913842163Preventing or attenuating amphotericin B nephrotoxicity with dopamine receptor agonists: a literature reviewIman Karimzadeh0Hossein Khalili1Mohammad Mahdi Sagheb2Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranNephrology-Urology Research Center and Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, IranNephrotoxicity is generally considered as the most clinically significant and dose-limiting adverse reaction of amphotericin B. Currently, only the clinical effectiveness of salt loading and administering lipid formulations of amphotericin B have been clearly demonstrated to prevent its nephrotoxicity. In this review, we collected the published data related to dopamine receptor agonists in preventing amphotericin B nephrotoxicity. A literature search was conducted by the relevant keywords like ‘‘amphotericin B”, “nephrotoxicity’’, and ‘‘dopamine’’ in databases such as Scopus, Medline, Embase and ISI Web of Knowledge. Four relevant articles were considered. Results of all the 3 experimental studies demonstrated that co-administration of dopamine (0.5-10 μg/kg/min) as continuous intravenous infusion, SK&F R-105058 (10 mg/kg twice daily), a prodrug of fenoldopam, orally, or fenoldopam, a relatively selective dopamine receptor type 1 agonist, (0.5 or 1 μg/kg/min) as continuous intravenous infusion can at least significantly mitigate the decrease in creatinine clearance caused by amphotericin B. Furthermore, fenoldopam and SK&F R-105058 can also protect against or delay amphotericin B-induced tubular damages. In contrast, the only clinical trial published until now found that simultaneous continuous intravenous infusion of low dose dopamine (3 μg/kg/min) had no beneficial effects on the incidence, severity, as well as time onset of developing amphotericin B-induced nephrotoxicity in autologous bone marrow transplant and leukemia patients. Considering the lack of beneficial effects in different settings such as acute kidney injury of any cause, negative results of the only clinical trial, and risk of significant adverse reactions, continuous intravenous infusion of low dose dopamine (1-3 μg/kg/min) or selective dopamine receptor type 1 agonists (e.g., fenoldopam) currently appears to have no real clinical role in preventing or attenuating amphotericin B nephrotoxicity.https://tips.sums.ac.ir/article_42163_857ba62c332b20974a84f35db067d48c.pdf
collection DOAJ
language English
format Article
sources DOAJ
author Iman Karimzadeh
Hossein Khalili
Mohammad Mahdi Sagheb
spellingShingle Iman Karimzadeh
Hossein Khalili
Mohammad Mahdi Sagheb
Preventing or attenuating amphotericin B nephrotoxicity with dopamine receptor agonists: a literature review
Trends in Pharmaceutical Sciences
author_facet Iman Karimzadeh
Hossein Khalili
Mohammad Mahdi Sagheb
author_sort Iman Karimzadeh
title Preventing or attenuating amphotericin B nephrotoxicity with dopamine receptor agonists: a literature review
title_short Preventing or attenuating amphotericin B nephrotoxicity with dopamine receptor agonists: a literature review
title_full Preventing or attenuating amphotericin B nephrotoxicity with dopamine receptor agonists: a literature review
title_fullStr Preventing or attenuating amphotericin B nephrotoxicity with dopamine receptor agonists: a literature review
title_full_unstemmed Preventing or attenuating amphotericin B nephrotoxicity with dopamine receptor agonists: a literature review
title_sort preventing or attenuating amphotericin b nephrotoxicity with dopamine receptor agonists: a literature review
publisher Shiraz University of Medical Sciences
series Trends in Pharmaceutical Sciences
issn 2423-5652
publishDate 2015-09-01
description Nephrotoxicity is generally considered as the most clinically significant and dose-limiting adverse reaction of amphotericin B. Currently, only the clinical effectiveness of salt loading and administering lipid formulations of amphotericin B have been clearly demonstrated to prevent its nephrotoxicity. In this review, we collected the published data related to dopamine receptor agonists in preventing amphotericin B nephrotoxicity. A literature search was conducted by the relevant keywords like ‘‘amphotericin B”, “nephrotoxicity’’, and ‘‘dopamine’’ in databases such as Scopus, Medline, Embase and ISI Web of Knowledge. Four relevant articles were considered. Results of all the 3 experimental studies demonstrated that co-administration of dopamine (0.5-10 μg/kg/min) as continuous intravenous infusion, SK&F R-105058 (10 mg/kg twice daily), a prodrug of fenoldopam, orally, or fenoldopam, a relatively selective dopamine receptor type 1 agonist, (0.5 or 1 μg/kg/min) as continuous intravenous infusion can at least significantly mitigate the decrease in creatinine clearance caused by amphotericin B. Furthermore, fenoldopam and SK&F R-105058 can also protect against or delay amphotericin B-induced tubular damages. In contrast, the only clinical trial published until now found that simultaneous continuous intravenous infusion of low dose dopamine (3 μg/kg/min) had no beneficial effects on the incidence, severity, as well as time onset of developing amphotericin B-induced nephrotoxicity in autologous bone marrow transplant and leukemia patients. Considering the lack of beneficial effects in different settings such as acute kidney injury of any cause, negative results of the only clinical trial, and risk of significant adverse reactions, continuous intravenous infusion of low dose dopamine (1-3 μg/kg/min) or selective dopamine receptor type 1 agonists (e.g., fenoldopam) currently appears to have no real clinical role in preventing or attenuating amphotericin B nephrotoxicity.
url https://tips.sums.ac.ir/article_42163_857ba62c332b20974a84f35db067d48c.pdf
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