Thermodynamics and kinetics guided probe design for uniformly sensitive and specific DNA hybridization without optimization

Thermodynamics and kinetics guided probe design for uniformly sensitive and specific DNA hybridization without optimization

Optimisation of nucleic acid probes and blocker strands can be laborious. Here the authors construct a theoretical model of competitive DNA hybridisation to design DNA probes for optimisation-free mutation detection.

Bibliographic Details
Main Authors: Xin Chen, Na Liu, Liquan Liu, Wei Chen, Na Chen, Meng Lin, Jiaju Xu, Xing Zhou, Hongbo Wang, Meiping Zhao, Xianjin Xiao
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12593-9

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