Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein.

Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein.

microRNAs (miRNAs) are single-stranded, 21- to 23-nucleotide cellular RNAs that control the expression of cognate target genes. Primary miRNA (pri-miRNA) transcripts are transformed to mature miRNA by the successive actions of two RNase III endonucleases. Drosha converts pri-miRNA transcripts to pre...

Full description

Bibliographic Details
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2005-07-01
Series:PLoS Biology
Online Access:http://dx.doi.org/10.1371/journal.pbio.0030236

Similar Items

Similar Items