An in silico approach towards identification of novel drug targets in pathogenic species of Leptospira.

An in silico approach towards identification of novel drug targets in pathogenic species of Leptospira.

Leptospirosis is one of the leading zoonotic infections worldwide. As with other infectious diseases, report of antimicrobial resistance to existing therapeutic arsenal poses challenges in the management of disease. Hence, identification of novel drug targets for the pathogen deems essential. Presen...

Full description

Bibliographic Details
Main Authors:	Reena Gupta, Rashi Verma, Dibyabhaba Pradhan, Arun Kumar Jain, Amineni Umamaheswari, Chandra Shekhar Rai
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2019-01-01
Series:	PLoS ONE
Online Access:	https://doi.org/10.1371/journal.pone.0221446

Similar Items

Discovery of potential lumazine synthase antagonists for pathogens involved in bacterial meningitis: In silico study
by: Manne Munikumar, et al.
Published: (2019-01-01)

Distribution of Plasmids in Distinct Leptospira Pathogenic Species.
by: Yanzhuo Wang, et al.
Published: (2015-11-01)

Responses of human endothelial cells to pathogenic and non-pathogenic Leptospira species.
by: Denise G Martinez-Lopez, et al.
Published: (2010-12-01)

Pathogenic Leptospira species in rodents from Corsica (France).
by: Elena Izquierdo-Rodríguez, et al.
Published: (2020-01-01)

Pathogenic Leptospira Species in Insectivorous Bats, China, 2015
by: Hui-Ju Han, et al.
Published: (2018-06-01)

Identification of attractive drug targets in neglected-disease pathogens using an in silico approach.
by: Gregory J Crowther, et al.
Published: (2010-01-01)

Direct detection and differentiation of pathogenic Leptospira species using a multi-gene targeted real time PCR approach.
by: Ana Sofia Ferreira, et al.
Published: (2014-01-01)

Multilocus sequence typing method for identification and genotypic classification of pathogenic <it>Leptospira </it>species
by: Machang'u Robert S, et al.
Published: (2006-11-01)

First molecular identification of two Leptospira species (Leptospira interrogans and Leptospira wolffii) in Bangladesh
by: M.A. Aziz, et al.
Published: (2019-09-01)

Leptospira interrogans and Leptospira kirschneri are the dominant Leptospira species causing human leptospirosis in Central Malaysia.
by: Noraini Philip, et al.
Published: (2020-03-01)

Leptospira interrogans and leptospira kirschneri are the dominant leptospira species causing human leptospirosis in central Malaysia
by: Affendy, N.B, et al.
Published: (2020)

A single multilocus sequence typing (MLST) scheme for seven pathogenic Leptospira species.
by: Siriphan Boonsilp, et al.
Published: (2013-01-01)

What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira.
by: Derrick E Fouts, et al.
Published: (2016-02-01)

In silico Prediction, Characterization, Molecular Docking, and Dynamic Studies on Fungal SDRs as Novel Targets for Searching Potential Fungicides Against Fusarium Wilt in Tomato
by: Mohd Aamir, et al.
Published: (2018-10-01)

THE OUTER MEMBRANE OF PATHOGENIC REPRESENTATIVES OF THE LEPTOSPIRA GENIUS
by: A. N. Vaganova
Published: (2014-06-01)

Hedgehogs and Mustelid Species: Major Carriers of Pathogenic Leptospira, a Survey in 28 Animal Species in France (20122015).
by: Florence Ayral, et al.
Published: (2016-01-01)

Development and validation of a real-time PCR for detection of pathogenic leptospira species in clinical materials.
by: Ahmed Ahmed, et al.
Published: (2009-09-01)

Assessment of animal hosts of pathogenic Leptospira in northern Tanzania.
by: Kathryn J Allan, et al.
Published: (2018-06-01)

The Role of Properdin in Killing of Non-Pathogenic Leptospira biflexa
by: Adriana Patricia Granados Martinez, et al.
Published: (2020-11-01)

Pathogenic Leptospira spp. in Bats, Madagascar and Union of the Comoros
by: Erwan Lagadec, et al.
Published: (2012-10-01)

Pathogenic Leptospira: Advances in understanding the molecular pathogenesis and virulence
by: Ciamak Ghazaei
Published: (2018-01-01)

Prevalence and Genotype Allocation of Pathogenic Leptospira Species in Small Mammals from Various Habitat Types in Germany.
by: Anna Obiegala, et al.
Published: (2016-03-01)

Distribution and Diversity of Pathogenic Leptospira Species in Peri-domestic Surface Waters from South Central Chile.
by: Meghan R Mason, et al.
Published: (2016-08-01)

Molecular Typing of Pathogenic <i>Leptospira</i> Species Isolated from Wild Mammal Reservoirs in Sardinia
by: Ivana Piredda, et al.
Published: (2021-04-01)

Detection of pathogenic Leptospira spp. By polymerase chain reaction reaction (PCR) targeting ligB gene
by: Fariba Fotohi, et al.
Published: (2014-10-01)

Evolving geographic diversity in SARS-CoV2 and in silico analysis of replicating enzyme 3CLpro targeting repurposed drug candidates
by: Nitin Chitranshi, et al.
Published: (2020-07-01)

In Silico Prediction of Therapeutic Drug Targets for Lung Cancer
by: Min-You Wu, et al.
Published: (2013)

In silico re-identification of properties of drug target proteins
by: Baeksoo Kim, et al.
Published: (2017-05-01)

<i>In Silico</i> Analysis of Genetic VapC Profiles from the Toxin-Antitoxin Type II VapBC Modules among Pathogenic, Intermediate, and Non-Pathogenic <i>Leptospira</i>
by: Alexandre P. Y. Lopes, et al.
Published: (2019-02-01)

Cats shedding pathogenic Leptospira spp.-An underestimated zoonotic risk?
by: Roswitha Dorsch, et al.
Published: (2020-01-01)

Pathogenic Leptospira spp. in Wild Rodents, Canary Islands, Spain
by: Pilar Foronda, et al.
Published: (2011-09-01)

Quantification of pathogenic Leptospira in the soils of a Brazilian urban slum.
by: Andrew G Schneider, et al.
Published: (2018-04-01)

Genotypes of pathogenic Leptospira spp isolated from rodents in Argentina
by: Sylvia Grune Loffler, et al.
Published: (2014-04-01)

Serovar diversity of pathogenic Leptospira circulating in the French West Indies.
by: Pascale Bourhy, et al.
Published: (2013-01-01)

An Optimized Method for Quantification of Pathogenic Leptospira in Environmental Water Samples.
by: Irina N Riediger, et al.
Published: (2016-01-01)

The detection of Burkholderia spp. and pathogenic Leptospira spp. in South Africa
by: Saif, Adrienne N.
Published: (2013)

<it>In silico </it>and microarray-based genomic approaches to identifying potential vaccine candidates against <it>Leptospira interrogans</it>
by: Jiang Xu-Cheng, et al.
Published: (2006-11-01)

Pathogenic Leptospira Secreted Proteases Target the Membrane Attack Complex: A Potential Role for Thermolysin in Complement Inhibition
by: Thais A. Amamura, et al.
Published: (2017-05-01)

Erythrokeratoderma en cocardes – A rare phenotype
by: P Arunprasath, et al.
Published: (2020-01-01)

Molecular Characterization of Leptospira spp. in Environmental Samples from North-Eastern Malaysia Revealed a Pathogenic Strain, Leptospira alstonii
by: Muhammad Azharuddin Azali, et al.
Published: (2016-01-01)