SIRT1 and FOXO Mediate Contractile Differentiation of Vascular Smooth Muscle Cells under Cyclic Stretch

SIRT1 and FOXO Mediate Contractile Differentiation of Vascular Smooth Muscle Cells under Cyclic Stretch

Background/Aims: Physiological mechanical stretch in vivo helps to maintain the quiescent contractile differentiation of vascular smooth muscle cells (VSMCs), but the underlying mechanisms are still unclear. Here, we investigated the effects of SIRT1 in VSMC differentiation in response to mechanical...

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Bibliographic Details
Main Authors: Kai Huang, Zhi-Qiang Yan, Dan Zhao, Si-Guo Chen, Li-Zhi Gao, Ping Zhang, Bao-Rong Shen, Hai-Chao Han, Ying-Xin Qi, Zong-Lai Jiang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Differentiation
SIRT1
FOXO
Vascular smooth muscle cells
Cyclic stretch
Online Access:http://www.karger.com/Article/FullText/438544

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