Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection

Dopamine agonists increase brain glutathione levels. Here the authors identify noncanonical signalling by Nrf2 as a potential mechanism for the neuroprotective effects of dopamine D2 receptor activation.

Bibliographic Details
Main Authors:	Yao Wei, Ming Lu, Meng Mei, Haoran Wang, Zhitao Han, Miaomiao Chen, Hang Yao, Nanshan Song, Xiao Ding, Jianhua Ding, Ming Xiao, Gang Hu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-14788-x

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spelling	doaj-5156e6f9d55642859a89acad2f5bd7472021-05-11T08:49:00ZengNature Publishing GroupNature Communications2041-17232020-02-0111111210.1038/s41467-020-14788-xPyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotectionYao Wei0Ming Lu1Meng Mei2Haoran Wang3Zhitao Han4Miaomiao Chen5Hang Yao6Nanshan Song7Xiao Ding8Jianhua Ding9Ming Xiao10Gang Hu11Department of Pharmacology, Nanjing University of Chinese MedicineJiangsu Key Laboratory of Neurodegeneration, Nanjing Medical UniversityDepartment of Pharmacology, Nanjing University of Chinese MedicineJiangsu Key Laboratory of Neurodegeneration, Nanjing Medical UniversityDepartment of Pharmacology, Nanjing University of Chinese MedicineJiangsu Key Laboratory of Neurodegeneration, Nanjing Medical UniversityJiangsu Key Laboratory of Neurodegeneration, Nanjing Medical UniversityJiangsu Key Laboratory of Neurodegeneration, Nanjing Medical UniversityDepartment of Pharmacology, Nanjing University of Chinese MedicineJiangsu Key Laboratory of Neurodegeneration, Nanjing Medical UniversityJiangsu Key Laboratory of Neurodegeneration, Nanjing Medical UniversityDepartment of Pharmacology, Nanjing University of Chinese MedicineDopamine agonists increase brain glutathione levels. Here the authors identify noncanonical signalling by Nrf2 as a potential mechanism for the neuroprotective effects of dopamine D2 receptor activation.https://doi.org/10.1038/s41467-020-14788-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yao Wei Ming Lu Meng Mei Haoran Wang Zhitao Han Miaomiao Chen Hang Yao Nanshan Song Xiao Ding Jianhua Ding Ming Xiao Gang Hu
spellingShingle	Yao Wei Ming Lu Meng Mei Haoran Wang Zhitao Han Miaomiao Chen Hang Yao Nanshan Song Xiao Ding Jianhua Ding Ming Xiao Gang Hu Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection Nature Communications
author_facet	Yao Wei Ming Lu Meng Mei Haoran Wang Zhitao Han Miaomiao Chen Hang Yao Nanshan Song Xiao Ding Jianhua Ding Ming Xiao Gang Hu
author_sort	Yao Wei
title	Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection
title_short	Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection
title_full	Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection
title_fullStr	Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection
title_full_unstemmed	Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection
title_sort	pyridoxine induces glutathione synthesis via pkm2-mediated nrf2 transactivation and confers neuroprotection
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-02-01
description	Dopamine agonists increase brain glutathione levels. Here the authors identify noncanonical signalling by Nrf2 as a potential mechanism for the neuroprotective effects of dopamine D2 receptor activation.
url	https://doi.org/10.1038/s41467-020-14788-x
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Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection

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