Imaging Biomarkers and Pathobiological Profiling in a Rat Model of Drug-Induced Interstitial Lung Disease Induced by Bleomycin

Imaging Biomarkers and Pathobiological Profiling in a Rat Model of Drug-Induced Interstitial Lung Disease Induced by Bleomycin

A large number of systemically administered drugs have the potential to cause drug-induced interstitial lung disease (DIILD). We aim to characterize a model of DIILD in the rat and develop imaging biomarkers (IBs) for detection and quantification of DIILD. In this study, Sprague–Dawley rats received...

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Bibliographic Details
Main Authors: Irma Mahmutovic Persson, Hanna Falk Håkansson, Anders Örbom, Jian Liu, Karin von Wachenfeldt, Lars E. Olsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Physiology
Subjects:
drug-induced interstitial lung disease
imaging
animal model
bleomycin
lung injury
magnetic resonance imaging
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00584/full

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