Exogenous L-carnitine ameliorates burn-induced cellular and mitochondrial injury of hepatocytes by restoring CPT1 activity

Exogenous L-carnitine ameliorates burn-induced cellular and mitochondrial injury of hepatocytes by restoring CPT1 activity

Abstract Background Impaired hepatic fatty acid metabolism and persistent mitochondrial dysfunction are phenomena commonly associated with liver failure. Decreased serum levels of L-carnitine, a amino acid derivative involved in fatty-acid and energy metabolism, have been reported in severe burn pat...

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Bibliographic Details
Main Authors: Pengtao Li, Zhengguo Xia, Weichang Kong, Qiong Wang, Ziyue Zhao, Ashley Arnold, Qinglian Xu, Jiegou Xu
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Nutrition & Metabolism
Subjects:
Carnitine
Burn
Mitochondrial injury
CPT1
Online Access:https://doi.org/10.1186/s12986-021-00592-x

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