Cyclosporine Lipid Nanocapsules as Thermoresponsive Gel for Dry Eye Management: Promising Corneal Mucoadhesion, Biodistribution and Preclinical Efficacy in Rabbits

Cyclosporine Lipid Nanocapsules as Thermoresponsive Gel for Dry Eye Management: Promising Corneal Mucoadhesion, Biodistribution and Preclinical Efficacy in Rabbits

An ophthalmic cyclosporine (CsA) formulation based on Lipid nanocapsules (LNC) was developed for dry eye management, aiming to provide targeting to ocular tissues with long-term drug levels and maximum tolerability. CsA-LNC were of small particle size (41.9 ± 4.0 nm), narrow size distribution (PdI ≤...

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Bibliographic Details
Main Authors: Lubna M. Eldesouky, Riham M. El-Moslemany, Alyaa A. Ramadan, Mahmoud H. Morsi, Nawal M. Khalafallah
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceutics
Subjects:
cylclosporine A
lipid nanocapsules
thermoresponsive gel
corneal delivery
dry eye
Online Access:https://www.mdpi.com/1999-4923/13/3/360

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https://www.mdpi.com/1999-4923/13/3/360

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