The Role of the Mitochondrial Genome in Ageing and Carcinogenesis

The Role of the Mitochondrial Genome in Ageing and Carcinogenesis

Mitochondrial DNA mutations and polymorphisms have been the focus of intensive investigations for well over a decade in an attempt to understand how they affect fundamental processes such as cancer and aging. Initial interest in mutations occurring in mitochondrial DNA of cancer cells diminished whe...

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Main Authors: Anna M. Czarnecka, Ewa Bartnik
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Journal of Aging Research
Online Access:http://dx.doi.org/10.4061/2011/136435
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spelling doaj-512ac8d0b738438e899260ffa89055952020-11-24T22:52:41ZengHindawi LimitedJournal of Aging Research2090-22122011-01-01201110.4061/2011/136435136435The Role of the Mitochondrial Genome in Ageing and CarcinogenesisAnna M. Czarnecka0Ewa Bartnik1Laboratory of Molecular Oncology, Department of Oncology, Military Institute of Medicine, ul. Szaserów 128, 01-141 Warsaw, PolandInstitute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Pawinskiego 5a, 02-106, Warsaw, PolandMitochondrial DNA mutations and polymorphisms have been the focus of intensive investigations for well over a decade in an attempt to understand how they affect fundamental processes such as cancer and aging. Initial interest in mutations occurring in mitochondrial DNA of cancer cells diminished when most were found to be the same mutations which occurred during the evolution of human mitochondrial haplogroups. However, increasingly correlations are being found between various mitochondrial haplogroups and susceptibility to cancer or diseases in some cases and successful aging in others.http://dx.doi.org/10.4061/2011/136435
collection DOAJ
language English
format Article
sources DOAJ
author Anna M. Czarnecka
Ewa Bartnik
spellingShingle Anna M. Czarnecka
Ewa Bartnik
The Role of the Mitochondrial Genome in Ageing and Carcinogenesis
Journal of Aging Research
author_facet Anna M. Czarnecka
Ewa Bartnik
author_sort Anna M. Czarnecka
title The Role of the Mitochondrial Genome in Ageing and Carcinogenesis
title_short The Role of the Mitochondrial Genome in Ageing and Carcinogenesis
title_full The Role of the Mitochondrial Genome in Ageing and Carcinogenesis
title_fullStr The Role of the Mitochondrial Genome in Ageing and Carcinogenesis
title_full_unstemmed The Role of the Mitochondrial Genome in Ageing and Carcinogenesis
title_sort role of the mitochondrial genome in ageing and carcinogenesis
publisher Hindawi Limited
series Journal of Aging Research
issn 2090-2212
publishDate 2011-01-01
description Mitochondrial DNA mutations and polymorphisms have been the focus of intensive investigations for well over a decade in an attempt to understand how they affect fundamental processes such as cancer and aging. Initial interest in mutations occurring in mitochondrial DNA of cancer cells diminished when most were found to be the same mutations which occurred during the evolution of human mitochondrial haplogroups. However, increasingly correlations are being found between various mitochondrial haplogroups and susceptibility to cancer or diseases in some cases and successful aging in others.
url http://dx.doi.org/10.4061/2011/136435
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