Ganglion Cell Complex thickness as an early predictor of microstructural changes in varying degrees of myopia in comparison with Retinal Nerve Fiber Layer (RNFL) thickness

• Main Authors: Andi Pratiwi Machmud, Andi Muhammad Ichsan, Habibah Setyawati Muhiddin
• Format: Article
• Language: English
• Published: DiscoverSys 2018-08-01
• Series: Bali Medical Journal
• Subjects: medicine
• Online Access: https://balimedicaljournal.org/index.php/bmj/article/view/861

<p>Purpose : To compare the Ganglion Cell Complex (GCC) thickness with Retinal Nerve Fiber Layer<br />(RNFL) thickness in correlation with visual field (VF) in varying degrees of myopia. Design: a Cross-<br />Sectional study. Participants: Ninety-six eyes of 49 patients with myopia. Methods: Patients with<br />myopia examined with streak retinoscope to obtained the best corrected visual acuity based on<br />spherical equivalent. Patients then divided into low (50 eyes=50.1%), moderate (31 eyes=32.3%), and<br />high (15=15.6%) myopia. Axial length measured with A-Scan ultrasound divided into short (4=4.2%),<br />moderate (74=77.1%), and long (18=18.7%). SD-OCT was used to measured GCC thickness in 9 areas<br />including fovea (R1), parafovea (R2-R5), and perifovea (R6-R9) according to early treatment diabetic<br />retinopathy study (ETDRS), and RNFL thickness in five areas (G, TS, TI, NS, N, NI). VF analysis<br />with humphrey field analyzer with SITA 24-2 pattern. Main outcome measures: GCC thickness has<br />higher correlation with degree of myopia particularly in perifovea area and means deviation than<br />RNFL thickness. Results: GCC thickness decreased significantly along with the elevation of myopia<br />degree in almost entire area except R1 and R5 . Parafovea (R2-R4) and perifovea (R6-R9) were<br />significantly correlated with p= 0.001, 0.005, 0.006 and p= 0.000, 0.000, 0.000, and 0.003<br />respectively. In contrast, RNFL thickness obtained lower correlation with myopia degree whereas the<br />only significant result was found in Nasal area (p= 0.045). VF found to be strongly correlated with the<br />degree of myopia in which p-value for Mean Deviation = 0.000. Conclusions: GCC thickness may<br />compare the predictive value of RNFL in predicting early retinal microstructural changes even in low<br />degree myopia. Financial Disclosure: Author has no financial disclosure.</p>