Anti-inflammatory Mechanism of Geniposide: Inhibiting the Hyperpermeability of Fibroblast-Like Synoviocytes via the RhoA/p38MAPK/NF-κB/F-Actin Signal Pathway
Geniposide (GE) is the extraction and purification of iridoid glycosides from the Gardenia jasminoides Ellis, which is a promising anti-inflammatory drug, but its mechanism of actions on rheumatoid arthritis (RA) has not been clarified. This study investigated the molecular mechanism behind GE reduc...
Main Authors: | Ran Deng, Feng Li, Hong Wu, Wen-yu Wang, Li Dai, Zheng-rong Zhang, Jun Fu |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-02-01
|
Series: | Frontiers in Pharmacology |
Online Access: | http://journal.frontiersin.org/article/10.3389/fphar.2018.00105/full |
Similar Items
-
A Microdialysis in Adjuvant Arthritic Rats for Pharmacokinetics–Pharmacodynamics Modeling Study of Geniposide with Determination of Drug Concentration and Efficacy Levels in Dialysate
by: Ran Deng, et al.
Published: (2018-04-01) -
Simvastatin alleviates hyperpermeability of glomerular endothelial cells in early-stage diabetic nephropathy by inhibition of RhoA/ROCK1.
by: Hui Peng, et al.
Published: (2013-01-01) -
Activation of mTOR mediates hyperglycemia-induced renal glomerular endothelial hyperpermeability via the RhoA/ROCK/pMLC signaling pathway
by: Xiaolin Chen, et al.
Published: (2021-10-01) -
Arp2/3-Branched Actin Maintains an Active Pool of GTP-RhoA and Controls RhoA Abundance
by: Yuxing Huang, et al.
Published: (2019-10-01) -
MiR-133b Promotes Neurite Outgrowth by Targeting RhoA Expression
by: Xiao Cheng Lu, et al.
Published: (2015-01-01)