Improved cardiac-specific delivery of RAGE siRNA within small extracellular vesicles engineered to express intense cardiac targeting peptide attenuates myocarditis

Improved cardiac-specific delivery of RAGE siRNA within small extracellular vesicles engineered to express intense cardiac targeting peptide attenuates myocarditis

Small extracellular vesicles (sEVs) are nanometer-sized membranous vesicles secreted by cells, with important roles in physiological and pathological processes. Recent research has established the application of sEVs as therapeutic vehicles in various conditions, including heart disease. However, th...

Full description

Bibliographic Details
Main Authors: Hyoeun Kim, Dasom Mun, Ji-Young Kang, Seung-Hyun Lee, Nuri Yun, Boyoung Joung
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
small extracellular vesicles
cardiac-targeting peptide
heart-specific delivery
small interfering RNA
myocarditis
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121001128

Similar Items

Similar Items