2-(Penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a Novel NQO1 Inducing Agent from Echinops grijsii Hance

A natural alkynol group-substituted thiophene, 2-(penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)-thiophene (PDDYT), was isolated from the roots of Echinops grijsii Hance. It possessed potent NAD(P)H: quinone oxidoreductase1 (NQO1) inducing activity and could activate Keap1-Nrf2 pathway effectively in...

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Main Authors:	Hai Jiang, Xiaoyu Zhang, Jing Shi
Format:	Article
Language:	English
Published:	MDPI AG 2010-08-01
Series:	Molecules
Subjects:	Echinops grijsii hance PDDYT NQO1 Nrf2 glutathione Akt
Online Access:	http://www.mdpi.com/1420-3049/15/8/5273/

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spelling	doaj-5120be1c6a9149e78c77f2cdc2c9a14d2020-11-24T22:19:24ZengMDPI AGMolecules1420-30492010-08-011585273528110.3390/molecules150852732-(Penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a Novel NQO1 Inducing Agent from Echinops grijsii HanceHai JiangXiaoyu ZhangJing ShiA natural alkynol group-substituted thiophene, 2-(penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)-thiophene (PDDYT), was isolated from the roots of Echinops grijsii Hance. It possessed potent NAD(P)H: quinone oxidoreductase1 (NQO1) inducing activity and could activate Keap1-Nrf2 pathway effectively in murine hepatoma Hepa 1c1c7 cells. Further investigations indicated that the activation of Keap1-Nrf2 pathway by PDDYT might be attributed to the activation of Akt and depleting the cellular glutathione (GSH). http://www.mdpi.com/1420-3049/15/8/5273/Echinops grijsii hancePDDYTNQO1Nrf2glutathioneAkt
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hai Jiang Xiaoyu Zhang Jing Shi
spellingShingle	Hai Jiang Xiaoyu Zhang Jing Shi 2-(Penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a Novel NQO1 Inducing Agent from Echinops grijsii Hance Molecules Echinops grijsii hance PDDYT NQO1 Nrf2 glutathione Akt
author_facet	Hai Jiang Xiaoyu Zhang Jing Shi
author_sort	Hai Jiang
title	2-(Penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a Novel NQO1 Inducing Agent from Echinops grijsii Hance
title_short	2-(Penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a Novel NQO1 Inducing Agent from Echinops grijsii Hance
title_full	2-(Penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a Novel NQO1 Inducing Agent from Echinops grijsii Hance
title_fullStr	2-(Penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a Novel NQO1 Inducing Agent from Echinops grijsii Hance
title_full_unstemmed	2-(Penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a Novel NQO1 Inducing Agent from Echinops grijsii Hance
title_sort	2-(penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a novel nqo1 inducing agent from echinops grijsii hance
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2010-08-01
description	A natural alkynol group-substituted thiophene, 2-(penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)-thiophene (PDDYT), was isolated from the roots of Echinops grijsii Hance. It possessed potent NAD(P)H: quinone oxidoreductase1 (NQO1) inducing activity and could activate Keap1-Nrf2 pathway effectively in murine hepatoma Hepa 1c1c7 cells. Further investigations indicated that the activation of Keap1-Nrf2 pathway by PDDYT might be attributed to the activation of Akt and depleting the cellular glutathione (GSH).
topic	Echinops grijsii hance PDDYT NQO1 Nrf2 glutathione Akt
url	http://www.mdpi.com/1420-3049/15/8/5273/
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2-(Penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a Novel NQO1 Inducing Agent from Echinops grijsii Hance

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