Protein Carbonylation and Aggregation Precede Neuronal Apoptosis Induced by Partial Glutathione Depletion
While the build-up of oxidized proteins within cells is believed to be toxic, there is currently no evidence linking protein carbonylation and cell death. In the present study, we show that incubation of nPC12 (neuron-like PC12) cells with 50 μM DEM (diethyl maleate) leads to a partial and transient...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2012-02-01
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| Series: | ASN Neuro |
| Online Access: | https://doi.org/10.1042/AN20110064 |