Facile Generation of Potent Bispecific Fab via Sortase A and Click Chemistry for Cancer Immunotherapy

Facile Generation of Potent Bispecific Fab via Sortase A and Click Chemistry for Cancer Immunotherapy

Bispecific antibodies (BsAbs) for T cell engagement have shown great promise in cancer immunotherapy, and their clinical applications have been proven in treating hematological malignance. Bispecific antibody binding fragment (BiFab) represents a promising platform for generating non-Fc bispecific a...

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Bibliographic Details
Main Authors:	Xuefei Bai, Wenhui Liu, Shijie Jin, Wenbin Zhao, Yingchun Xu, Zhan Zhou, Shuqing Chen, Liqiang Pan
Format:	Article
Language:	English
Published:	MDPI AG 2021-09-01
Series:	Cancers
Subjects:	bispecific antibody sortase A chemo-enzymatic approach anti-CD20 antibody Fab BiFab
Online Access:	https://www.mdpi.com/2072-6694/13/18/4540

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