Long-term follow-up of pediatric patients with nephrotic syndrome treated at Hospital Universitario San Vicente de Paúl (Medellín (HUSVP), Colombia), between January 1960 and December 2009 = Evolución a largo plazo de los niños con diagnóstico de síndrome nefrótico atendidos en el Hospital Universitario San Vicente de Paúl, Medellín, entre enero de 1960 y diciembre de 2009

• Main Authors: Atehortúa Baena, Paola Shyrley, Piedrahíta Echevery, Vilma, Vanegas Ruiz, Juan José, Vélez Echeverri, Catalina, Serna Higuita, Lina María, Serrano Gayubo, Ana Katherina, Flórez, Jesús Antonio, Cornejo Ochoa, William, Martínez Salas, José
• Format: Article
• Language: Spanish
• Published: Universidad de Antioquia 2013-04-01
• Series: Iatreia
• Subjects: Chronic Renal Insufficiency; Cyclophosphamide; Nephrotic Syndrome; Ciclofosfamida; Insuficiencia Renal Crónica; Síndrome Nefrótico
• Online Access: http://www.iatreia.udea.edu.co/index.php/iatreia/article/view/14353/13108

Introduction: Nephrotic syndrome (NS) is a glomerular disease that frequently affects children. There have been few studies on it in Colombia.Objective: To describe the clinical and epidemiological features of children with SN treated at HUSVP between 1960 and 2009.Methodology: Retrospective and descriptive study.Results: Steroid-sensitive nephrotic syndrome was diagnosed in 87.9% of the patients, and between 1.7%-5.4% turned steroid-resistant. Biopsies revealed disease with minimal changes in 43.6% and focal segmental glomerulosclerosis in 37.3%. Additional immunosuppressive therapy was required by 40% of the patients; in 88.8% of these, cyclophosphamide was used, and remission was achieved in 85.7%. In 56% of the cases there were complications that were infectious in 52%. Nine percent of the patients progressed to end-stage renal disease. Mortality rate was 5.7%.Discussion: The large number of patients with nephrotic syndrome studied in this series and the long period of follow-up (up to 35 years) provide valuable information about the clinical behavior of this syndrome in Colombia and on its response to immunosuppressive therapy.