COVID-19 and cause of pregnancy loss during the pandemic: A systematic review.

<h4>Introduction</h4>The association between Coronavirus Disease 2019 (COVID-19) and abortion has been debated since the beginning of the COVID-19 pandemic. We aimed to conduct this systematic review to understand better the potential effects of Severe Acute Respiratory Syndrome Coronavi...

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Main Authors: Seyyedeh Neda Kazemi, Bahareh Hajikhani, Hamidreza Didar, Sareh Sadat Hosseini, Sara Haddadi, Farima Khalili, Mehdi Mirsaeidi, Mohammad Javad Nasiri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0255994
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spelling doaj-51080783abc343e3b7708693cdbf4dc02021-08-17T04:30:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01168e025599410.1371/journal.pone.0255994COVID-19 and cause of pregnancy loss during the pandemic: A systematic review.Seyyedeh Neda KazemiBahareh HajikhaniHamidreza DidarSareh Sadat HosseiniSara HaddadiFarima KhaliliMehdi MirsaeidiMohammad Javad Nasiri<h4>Introduction</h4>The association between Coronavirus Disease 2019 (COVID-19) and abortion has been debated since the beginning of the COVID-19 pandemic. We aimed to conduct this systematic review to understand better the potential effects of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) on fetal loss in infected mothers presented with abortion following this infection.<h4>Methods</h4>We included articles published in PubMed/Medline, Web of Science, clinicaltrials.gov, and Embase databases in 2019 and 2020 through a comprehensive search via appropriate keywords, including COVID-19 and abortion synonyms. All studies with the abortion data in COVID-19 confirmed pregnant females were collected.<h4>Results</h4>Out of 208 potentially relevant articles, 11 articles were eligible to include in the systematic review. The included reports were published because of the following reasons: (1) First-trimester miscarriage; (2) Late miscarriage; (3) complication of COVID-19 infection in pregnancy; (4) COVID-19 disease in artificial pregnancy. First-trimester abortion was found in 5 studies, and second-trimester abortion in 7 studies. Two patients acquired infection during the hospital stay while they were referred for abortion. Reports related to abortion in pregnant females with COVID-19 show that most miscarriages due to COVID-19 in the first trimester were due to placental insufficiency.<h4>Conclusions</h4>There is an increased risk of abortion in mothers with a positive test result of SARS-CoV-2, which several case reports and case series have identified during the pandemic. Placental inflammation during the viral infection may result in fetal growth retardation and induce abortion. There has not been any consistent evidence of vertical transmission of the virus from mother to fetus, which requires further investigation.https://doi.org/10.1371/journal.pone.0255994
collection DOAJ
language English
format Article
sources DOAJ
author Seyyedeh Neda Kazemi
Bahareh Hajikhani
Hamidreza Didar
Sareh Sadat Hosseini
Sara Haddadi
Farima Khalili
Mehdi Mirsaeidi
Mohammad Javad Nasiri
spellingShingle Seyyedeh Neda Kazemi
Bahareh Hajikhani
Hamidreza Didar
Sareh Sadat Hosseini
Sara Haddadi
Farima Khalili
Mehdi Mirsaeidi
Mohammad Javad Nasiri
COVID-19 and cause of pregnancy loss during the pandemic: A systematic review.
PLoS ONE
author_facet Seyyedeh Neda Kazemi
Bahareh Hajikhani
Hamidreza Didar
Sareh Sadat Hosseini
Sara Haddadi
Farima Khalili
Mehdi Mirsaeidi
Mohammad Javad Nasiri
author_sort Seyyedeh Neda Kazemi
title COVID-19 and cause of pregnancy loss during the pandemic: A systematic review.
title_short COVID-19 and cause of pregnancy loss during the pandemic: A systematic review.
title_full COVID-19 and cause of pregnancy loss during the pandemic: A systematic review.
title_fullStr COVID-19 and cause of pregnancy loss during the pandemic: A systematic review.
title_full_unstemmed COVID-19 and cause of pregnancy loss during the pandemic: A systematic review.
title_sort covid-19 and cause of pregnancy loss during the pandemic: a systematic review.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2021-01-01
description <h4>Introduction</h4>The association between Coronavirus Disease 2019 (COVID-19) and abortion has been debated since the beginning of the COVID-19 pandemic. We aimed to conduct this systematic review to understand better the potential effects of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) on fetal loss in infected mothers presented with abortion following this infection.<h4>Methods</h4>We included articles published in PubMed/Medline, Web of Science, clinicaltrials.gov, and Embase databases in 2019 and 2020 through a comprehensive search via appropriate keywords, including COVID-19 and abortion synonyms. All studies with the abortion data in COVID-19 confirmed pregnant females were collected.<h4>Results</h4>Out of 208 potentially relevant articles, 11 articles were eligible to include in the systematic review. The included reports were published because of the following reasons: (1) First-trimester miscarriage; (2) Late miscarriage; (3) complication of COVID-19 infection in pregnancy; (4) COVID-19 disease in artificial pregnancy. First-trimester abortion was found in 5 studies, and second-trimester abortion in 7 studies. Two patients acquired infection during the hospital stay while they were referred for abortion. Reports related to abortion in pregnant females with COVID-19 show that most miscarriages due to COVID-19 in the first trimester were due to placental insufficiency.<h4>Conclusions</h4>There is an increased risk of abortion in mothers with a positive test result of SARS-CoV-2, which several case reports and case series have identified during the pandemic. Placental inflammation during the viral infection may result in fetal growth retardation and induce abortion. There has not been any consistent evidence of vertical transmission of the virus from mother to fetus, which requires further investigation.
url https://doi.org/10.1371/journal.pone.0255994
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