Association between serum tissue inhibitor of matrix metalloproteinase-1 levels and mortality in patients with severe brain trauma injury.

<h4>Objective</h4>Matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) play a role in neuroinflammation after brain trauma injury (TBI). Previous studies with small sample size have reported higher circulating MMP-2 and MMP-9 levels in patients with...

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Main Authors: Leonardo Lorente, María M Martín, Patricia López, Luis Ramos, José Blanquer, Juan J Cáceres, Jordi Solé-Violán, Jorge Solera, Judith Cabrera, Mónica Argueso, Raquel Ortiz, María L Mora, Santiago Lubillo, Alejandro Jiménez, Juan M Borreguero-León, Agustín González, Josune Orbe, José A Rodríguez, José A Páramo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24728097/?tool=EBI