Formation and antiproliferative effect of prostaglandin E3 from eicosapentaenoic acid in human lung cancer cells

Formation and antiproliferative effect of prostaglandin E3 from eicosapentaenoic acid in human lung cancer cells

We investigated the formation and pharmacology of prostaglandin E3 (PGE3) derived from fish oil eicosapentaenoic acid (EPA) in human lung cancer A549 cells. Exposure of A549 cells to EPA resulted in the rapid formation and export of PGE3. The extracellular ratio of PGE3 to PGE2 increased from 0.08 i...

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Bibliographic Details
Main Authors: Peiying Yang, Diana Chan, Edward Felix, Carrie Cartwright, David G. Menter, Timothy Madden, Russell D. Klein, Susan M. Fischer, Robert A. Newman
Format: Article
Language:English
Published: Elsevier 2004-06-01
Series:Journal of Lipid Research
Subjects:
ω-3 fatty acids
eicosanoid metabolism
cell proliferation
cyclooxygenase enzymes
malignant cells
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520318009

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http://www.sciencedirect.com/science/article/pii/S0022227520318009

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