Comprehensive Model for Epidermal Growth Factor Receptor Ligand Binding Involving Conformational States of the Extracellular and the Kinase Domains

Comprehensive Model for Epidermal Growth Factor Receptor Ligand Binding Involving Conformational States of the Extracellular and the Kinase Domains

The epidermal growth factor (EGF) receptor (EGFR) undergoes ligand-dependent dimerization to initiate transmembrane signaling. Although crystallographic structures of the extracellular and kinase domains are available, ligand binding has not been quantitatively analyzed taking the influence of both...

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Bibliographic Details
Main Authors: Tímea Hajdu, Tímea Váradi, István Rebenku, Tamás Kovács, János Szöllösi, Peter Nagy
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
EGF receptor
ligand binding
cooperativity
dimerization
kinase domain
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00776/full

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