Calcium Chloride Modified Alginate Microparticles Formulated by the Spray Drying Process: A Strategy to Prolong the Release of Freely Soluble Drugs

Calcium Chloride Modified Alginate Microparticles Formulated by the Spray Drying Process: A Strategy to Prolong the Release of Freely Soluble Drugs

Alginate (ALG) cross-linking by CaCl2 is a promising strategy to obtain modified-release drug delivery systems with mucoadhesive properties. However, current technologies to produce CaCl2 cross-linked alginate microparticles possess major disadvantages, such as a poor encapsulation efficiency of wat...

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Bibliographic Details
Main Authors: Marta Szekalska, Katarzyna Sosnowska, Anna Czajkowska-Kośnik, Katarzyna Winnicka
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Materials
Subjects:
polymer cross-linking
alginate modification
calcium chloride
microparticles
spray drying
prolonged drug release
Online Access:http://www.mdpi.com/1996-1944/11/9/1522

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